Table 1

Splenectomy in patients with refractory aPL associated cytopenias: reported cases

Case	Author (date)	Diagnosis	aPL	Age/sex	Cytopenia	Outcome	Current treatment
1	Ballerini et al(1995)18	PAPS	IgG	23/F	Thromb	CR	—
2	Leuzzi et al(1997)17	PAPS	IgG, IgM	35/F	Thromb	CR	—
3	Leuzzi et al(1997)17	PAPS	IgG, IgM	33/F	Thromb	CR	—
4	Hakim et al(1998)19	PAPS	IgG	39/F	Thromb	CR	—
5	Hakim et al(1998)19	PAPS	IgG	23/F	Thromb	CR	—
6	Hakim et al(1998)19	PAPS	IgG	40/F	Thromb	CR	—
7	Hakim et al(1998)19	SLE	IgG	37/F	Thromb	CR	Pred, HCQ
8	Hakim et al(1998)19	SLE	IgG	28/F	Thromb	CR	Pred, MTX
9	Hakim et al(1998)19	SLE	IgG	40/F	Thromb	CR	Pred, AZA
10	Galindo et al(1999)20	SLE	IgM	30/F	Thromb	CR	Pred, HCQ
11	Galindo et al(1999)20	SLE	LA	41/F	Thromb	CR	Pred, HCQ
12	Galindo et al(1999)20	SLE	LA, IgG	25/F	Thromb	CR	Pred, HCQ
13	Galindo et al(1999)20	SLE	LA, IgG, IgM	36/F	Thromb	CR	Pred, AZA
14	Galindoet al(1999)20	SLE	LA	58/F	Thromb	CR	Pred
15	Galindo et al(1999)20	PAPS	LA, IgG, IgM	35/F	Thromb, HA	CR	Pred
16	Galindo et al(1999)20	SLE	IgG	47/F	Thromb	CR	HCQ
17	Galindo et al(1999)20	SLE	IgG, IgM	22/F	Thromb	CR	Pred, CQ
18	Galindoet al (1999)20	SLE	LA, IgG, IgM	36/F	Thromb, HA	CR	Pred
19	Galindoet al(1999)20	PAPS	LA	47/M	Thromb	PR	Pred
20	Galindo et al(1998)20	SLE	LA, IgG	52/F	Thromb	PR	HCQ
21	Present study	PAPS	IgM	60/F	Thromb, HA	CR	—
22	Present study	LLD	IgG, IgM	32/F	Thromb, HA	CR	—

aPL= antiphospholipid antibodies; PAPS = primary antiphospholipid syndrome; SLE = systemic lupus erythematosus; LLD = lupus-like disease; LA = lupus anticoagulant; F = female; M = male; Thromb = thrombocytopenia; HA = haemolytic anaemia; CR = complete remission; PR = partial remission; Pred = prednisone; HCQ = hydroxychloroquine; MTX = methotrexate; AZA = azathioprine; CQ = chloroquine.