Pregnancies in patients with a known Wegener's granulomatosis (WG) or WG before pregnancy in remission at pregnancy onset
| Author, reference | Age at WG onset (years) | Organs initially affected2-150 | Initial treatment2-151 | Age at pregnancy (years) | Complication/ treatment | Pregnancy outcome2-154Gestational age (weeks)/ weight (kg) | ||||||
| Cooper10 | 25 | E, L | AZA, CS, Radiotherapy | ND | Respiratory infection treated with penicilline+ hydrocortisone | Membranes rupture induced VD | ||||||
| 35/2.63 | ||||||||||||
| Harrison14 | 16 | E, L | AZA, CS | P12-152: ND | Normal | |||||||
| P2: ND | Normal | |||||||||||
| P3: ND | Relapse (L) | Normal | ||||||||||
| Biesenbach9 | 20 | E, L, K | oCY, CS | 22 | T32-152: Pre-eclampsia | Caesarean section | ||||||
| Renal transplant | Twin | |||||||||||
| CS, CsA | 33/1.350–1.18 | |||||||||||
| Fields6 | 18 | E, L, K, S, A | CY, CS | 23 | T2: Relapse | Caesarean section | ||||||
| (E, L, S, K) | 33/2.04 | |||||||||||
| oCY + CS + haemodialysis | ||||||||||||
| Pauzner8 | 30 | E, L, K, S | OCY, CS | P1: 31 | T2: Relapse OS + laser | VD 38/2.77 | ||||||
| AZA TS | ||||||||||||
| Lima7 | 29 | E, A | pCY | P1: 32 | VD 40/3.17 | |||||||
| AZA, CS | P2: 33 | VD 39/3.74 | ||||||||||
| Parnham15 | 21 | L, K, S, A | PC, PE, CS, | 24 | T2: Relapse | Induced VD | ||||||
| CS TS | (E, L, K) | 37/2.87 | ||||||||||
| oCY + CS | ||||||||||||
| AZA + CS | ||||||||||||
| Oligohydramnios | ||||||||||||
| Koldingsnes18 | 23 | E, K | CS pCY | 28 | Postpartum relapse | Normal | ||||||
| AZA, CS | ND/3.56 | |||||||||||
| Present report No 1 | 30 | E, L, A | pCY, CS | P1: 32 | Therapeutic abortion for encephalocele | |||||||
| Hydrocortisone, TS | P2: 33 | Pre-eclampsia | Caesarean section 37/4.17 | |||||||||
| P3: 35 | Retroplacental haematoma | Caesarean section | ||||||||||
| Macrosomia | 35/4.62 | |||||||||||
| Present report No 2 | 27 | E, L, K, A | pCY, CS | 31 | Pre-eclampsia | Induced VD | ||||||
| pCY, CS, TS | 35/3.12 | |||||||||||
| Present report No 3 | 20 | E,L | Laser | 34 | Dystocia | Caesarean section | ||||||
| TS | 39/3.75 | |||||||||||
| MTX, CS | ||||||||||||
↵2-150 A = arthralgia or arthritis; E = upper respiratory tract (ear, nose, throat) and eyes; K = kidney; L = lung and lower respiratory tract; S = skin.
↵2-151 AZA = azathioprine; CS = corticosteroids; CsA = cyclosporin; CY = cyclophosphamide; oCY = oral CY; pCY = intravenous pulses of CY; MTX = methotrexate; PE = plasma exchanges; TS = trimethoprim-sulfamethoxazole.
↵2-152 P1, P2, P3 = first, second, third pregnancy; T1, T2, T3 = first, second, third trimester.
↵2-154 VD = vaginal delivery; ND = no data.