Table 1

Pregnancies in patients with a known Wegener's granulomatosis (WG) or WG before pregnancy active at pregnancy onset

Author, reference

Age at WG onset (years)

Organs initially affected^1-150

Initial treatment^1-151

Age at pregnancy (years)

Organs affected at pregnancy onset

Complication/ treatment

Pregnancy outcome

M'Rad12

E, L, S, A

E, S L, K

Relapse (L, S)

Therapeutic abortion

oCY

Maternal death

Pauzner⁸

E, L, K, S

oCY, CS

P2^1-152:32

Subglottic stenosis

Therapeutic abortion

AZA TS

Lima⁷

E, L, S, A

pCY CS

S, A

Relapse T1^1-152 (L, S, A)

Spontaneous abortion

Kumar16

E, K

oCY, CS

E, A

Relapse T1 (E, A)

Spontaneous abortion

Postpartum flare (L)

↵1-150 A = arthralgia or arthritis; E = upper respiratory tract (ear, nose, throat) and eyes; K = kidney; L = lung and lower respiratory tract; S = skin.
↵1-151 AZA = azathioprine; CS = corticosteroids; CY = cyclophosphamide; oCY = oral CY; pCY = intravenous pulses of CY; TS = trimethoprim-sulfamethoxazole.
↵1-152 P2 = second pregnancy; T1 = first trimester.