Genotypic and allelic frequencies of GM/KM allotypes in SSc patients and normal controls
| Ig allotypes | SSc (n=105) | Normal controls (n=47) | p Value | OR (95% CI) | |
|---|---|---|---|---|---|
| Genotypic frequency (%) | |||||
| G1M | f | 1 | 0 | ns | — |
| z | 79 | 89 | ns | 0.44 (0.14 to 1.5) | |
| f,z | 21 | 11 | ns | 2.1 (0.61 to 7.2) | |
| G2M | n+ | 1 | 0 | ns | — |
| n− | 78 | 87 | ns | 0.52 (0.16 to 1.7) | |
| n+,n− | 21 | 13 | ns | 1.8 (0.55 to 6.0) | |
| G3M | b | 7 | 0 | ns | — |
| g | 70 | 77 | ns | 0.73 (0.25 to 2.1) | |
| b,g | 15 | 11 | ns | 1.5 (0.31 to 7.5) | |
| untypable* | 8 | 13 | ns | 0.56 (0.12 to 2.7) | |
| KM | (1,2) | 9 | 9 | ns | 1.0 (0.96 to 1.1) |
| 3 | 45 | 49 | ns | 0.85 (0.29 to 2.5) | |
| (1, 2),3 | 47 | 43 | ns | 1.2 (0.39 to 3.6) | |
| Allelic frequency (%) | |||||
| G1M | f | 21 | 11 | ns | 2.2 (0.67 to 7.4) |
| z | 99 | 100 | ns | — | |
| G2M | n+ | 22 | 13 | ns | 1.9 (0.60 to 6. 1) |
| n− | 99 | 100 | ns | 2.3 (0 to 105) | |
| G3M† | b | 24 | 12 | ns | 2.2 (0.67 to 7.5) |
| g | 93 | 100 | ns | — | |
| KM | 1 | 0 | 0 | ns | — |
| (1,2) | 55 | 51 | ns | 1.2 (0.40 to 3.5) | |
| 3 | 91 | 91 | ns | 1.0 (0.94 to 1.0) | |
ns = Not significant (p>0.05). *G3M could not be typed in a total of 14 subjects. †Eight SSc patients and six normal controls in whom G3M was untypable were excluded.