Immune consequence of cytokine/anticytokine treatment in human trials
| IL10 | TNFa inhibition | IL1 inhibition | IL6 inhibition | |
|---|---|---|---|---|
| lymphocytes count | ↘ (transient) | ↗ | no change | ↘ (transient) |
| CD4/CD8 ratio | no change | no change | no change | no change |
| T cell response | ↘ (anergy) | ↗ | ↘ | ? |
| Th1/Th2 shift | →Th2 | ? | ? | ? |
| monocytes count | ↗ | ↘ | no change | ? |
| monocytes activity | ↘ | ? | ? | ? |
| blood monocytes DR expression | ↘ | no change | no change | ? |