Plasma homocysteine (μmol/l), serum folate (nmol/l), and vitamin B12 (pmol/l) and differences with week 0
| Wk 0 | Wk 4 | −Wk 0 | Wk 8 | −Wk 0 | Wk 24 | −Wk 0 | Wk 52 | −Wk 0 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hcys | Folate | vit B12 | Hcys | Folate | Hcys | Folate | Hcys | Folate | Hcys | Folate | |||||||||
| SSZ, n | 34 | 34 | 34 | 31 | 31 | 30 | 30 | 26 | 26 | 22 | 22 | ||||||||
| Median | 14.1 | 10.0 | 205 | 1.1 | 0.0 | 1.5 | −0.5 | 1.0 | −0.1 | 0.6 | 0.2 | ||||||||
| P25 | 12.1 | 6.7 | 158 | 0.6 | −1.8 | 0.2 | −2.0 | −0.5 | −1.6 | −1.1 | −1.9 | ||||||||
| P75 | 17.1 | 12.0 | 287 | 2.5 | 1.0 | 2.7 | 1.3 | 3.0 | 1.7 | 2.7 | 2.9 | ||||||||
| MTX, n | 35 | 35 | 35 | 35 | 35 | 35 | 35 | 33 | 33 | 33 | 33 | ||||||||
| Median | 14.1 | 9.5 | 220 | 1.6 | −2.2 | 2.4 | −2.4 | 3.9 | −2.9 | 3.1 | −3.0 | ||||||||
| P25 | 12.1 | 8.4 | 170 | 0.9 | −3.0 | 0.5 | −3.5 | 1.1 | −4.4 | 0.5 | −4.3 | ||||||||
| P75 | 16.2 | 13.0 | 260 | 3.1 | −1.1 | 4.1 | −0.4 | 5.1 | −1.3 | 5.8 | −1.7 | ||||||||
| COMBI, n | 36 | 36 | 36 | 35 | 35 | 34 | 34 | 32 | 32 | 30 | 30 | ||||||||
| Median | 14.8 | 8.7 | 210 | 2.3 | −1.5 | 3.9 | −2.3 | 5.4 | −2.5 | 4.0 | −2.0 | ||||||||
| P25 | 12.5 | 6.5 | 170 | 1.2 | −3.0 | 0.8 | −3.0 | 3.7 | −4.3 | 2.0 | −4.7 | ||||||||
| P75 | 16.8 | 11.0 | 340 | 4.8 | −0.2 | 5.7 | −0.8 | 8.7 | −0.7 | 7.6 | −0.7 | ||||||||
SSZ: sulphasalazine, MTX: methotrexate, COMBI: SSZ+MTX, Hcys: plasma homocysteine concentration. Normal value of of serum folate:>5.0 nmol/l, vitamin B12:>150 pmol/l.