Multiple myeloma | Rheumatoid arthritis | Haemodialysis | Control | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A(−) | A(+) | A(−) | A(+) | A(−) | A(+) | ||||||||
Number (female) | 13 (5) | 8 (1) | 50 (44) | 45 (42) | 41 (14) | 32 (17) | 41 (17) | ||||||
Age (y) | 60 (7) | 59 (10) | 63 (11) | 62 (10) | 54 (12) | 58 (9) | 60 (10) | ||||||
Proteinuria* (%) | 77 | 83 | 0 | 27 | — | — | 0 | ||||||
Albumin (g/dl) | 3.3 (0.4) | 2.9 (0.6) | 3.4 (0.4) | 3.3 (0.5) | ND | ND | 4.1 (0.2) | ||||||
ApoAI (mg/dl) | 114 (35) | 111 (39) | 116 (26) | 124 (29) | 123 (21) | 127 (20) | 133 (29) | ||||||
p Value vC† | NS | NS | 0.003 | NS | NS | NS | — | ||||||
vA(−)‡ | — | NS | — | NS | — | NS | — | ||||||
ApoAII (mg/dl) | 27 (8) | 21 (8) | 25 (6) | 21 (7) | 28 (5) | 26 (4) | 35 (6) | ||||||
p Value vC | 0.0004 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | — | ||||||
vA(−) | — | NS | — | 0.002 | — | 0.03 | — | ||||||
ApoAII/ApoAI | 0.24 (0.03) | 0.19 (0.04) | 0.22 (0.03) | 0.17 (0.04) | 0.23 (0.03) | 0.20 (0.03) | 0.27 (0.05) | ||||||
p Value vC | NS | 0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | — | ||||||
vA(−) | — | 0.002 | — | <0.0001 | — | <0.0001 | — | ||||||
Diagnostic§ | |||||||||||||
sensitivity (%) | 50 | 80 | 46 | ||||||||||
specificity (%) | 100 | 78 | 90 |
Data are shown as mean (SD). A(−): without amyloidosis, A(+): with amyloidosis, NS: not significant, ND: not determined. *Positive by dipstick test, †versus control, ‡versus subjects without amyloidosis in each patient group. §Diagnostic efficiency for amyloidosis in each patient group when the apoAII/AI ratio of 0.2 is adapted as cut off value.