Side effects between AM
| Side effect | AM n (%) | CQ n (%) | HCQ n (%) | p Value |
|---|---|---|---|---|
| Total number of patients | 940 | 541 | 399 | |
| Mucocutaneous | 33 (3.5) | 25 (4.6) | 8 (2) | NS |
| Rash | 31 (2.4) | 23 (4.3) | 8 (2) | <0.05 |
| Hair bleaching | 2 (0.2) | 2 (0.4) | 0 (0) | NS |
| Ocular | 70 (7.4) | 63 (11.7) | 9 (2.2) | <0.0001 |
| Corneal deposits | 41 (4.4) | 38 (7) | 3 (0.8) | <0.00001 |
| Blurred vision | 26 (2.8) | 21 (3.9) | 5 (1.3) | <0.01 |
| Retinal changes5-150 | 3 (0.3) | 2 (0.3) | 1 (0.2) | NS |
| Gastrointestinal | 67 (7.1) | 34 (6.3) | 33 (8.2) | NS |
| Nausea/vomiting | 46 (4.9) | 26 (4.8) | 20 (5) | NS |
| Diarrhoea | 14 (1.5) | 5 (0.9) | 9 (2.3) | NS |
| Abdominal pain | 7 (0.7) | 3 (0.6) | 4 (1) | NS |
| Neuromuscular | 19 (2) | 17 (3.2) | 2 (0.5) | NS |
| Headache | 9 (1) | 7 (1.3) | 2 (0.5) | NS |
| Nightmares | 4 (0.4) | 4 (0.7) | 0 (0.0) | NS |
| Myopathy | 6 (0.6) | 6 (1.1) | 0 (0) | 0<0.03 |
| Unknown | 23 (2.4) | 16 (2.9) | 7 (1.7) | NS |
| Total | 212 (22.6) | 153 (28.4) | 59 (14.7) | <0.00001 |
↵5-150 Only one patient was confirmed to have a true retinopathy (see text).