Table 3

LMP2CfoI genotypes in Mexican AS patients stratified by age at onset and history of AAU

LMP2-CfoI genotype
AA (%) AB (%) BB (%)
Guadalajara3-150
 Juveniles
  AAU+01  (50)1  (50)
  AAU−03 (20)12 (80)
 Adults
  AAU+2  (22.2)2 (22.2)5 (55.6)
  AAU−2 (3.1)17 (26.6)45 (70.3)
Mexico City3-151
 Juveniles
  AAU+2 (16.7)4 (33.3)6 (50)
  AAU−014 (35)26 (65)
 Adults
  AAU+02 (66.7)1 (33.3)
  AAU−2 (8.0)5 (20)18 (72)
  • 3-150 Stratified exact OR = 2.12 (95% CI, 0.46, 9.24; p = 0.40).

  • 3-151 Stratified exact OR = 2.27 (95% CI, 0.62, 8.54; p = 0.25).

  • Combined population stratified exact OR = 2.30 (95% CI, 0.90, 5.91; p = 0.087). OR = The exact conditional maximum likelihood estimates, stratified by age at onset of disease, for the odds ratio relating LMP2A allelic frequency and history of AAU.