Effects of gonadal and adrenal (cortisol and DHEA) steroid hormones on macrophage, Th1-type and Th2-type cytokine production
| Cytokine | Hormone | |||
|---|---|---|---|---|
| Cortisol | Estradiol | Testosterone | DHEA | |
| Macrophage | ||||
| IL1 | − | + 1-150/− † | − | ? |
| IL6 | − | ? | ? | − |
| TNFα | − | + 1-150/−† | − | ? |
| IL12 | − | ? | − | ? |
| Th1-type | ||||
| IFNγ | − | ? | ? | + |
| IL2 | − | ? | ? | + |
| Th2-type | ||||
| IL4 | + | ? | ? | ? |
| IL10 | + | + | + | ? |
| IL13 | + | ? | ? | ? |
↵1-150 = Physiological concentrations, † = pharmacological concentrations, + = enhancement of cytokine production, − = inhibition of cytokine production, ? = not determined.