Clinical association of antibodies to 52-Kda (Ro52) and 60-Kda(Ro60) Ro/SS-A proteins in patients with SSc
| Reactivity to Ro/SS-A antigens | ||||
| Ro52 and Ro60 | Ro52 alone | Ro60 alone | Ro/SS-A antigen negative | |
| Number | 15 | 5 | 7 | 236 |
| Clinical features | ||||
| Diffuse:limited | 5:10 | 3:2 | 3:4 | 135:101 |
| Raynaud’s phenomenon | 14/15 | 4/5 | 7/7 | 213/236 |
| Pitting scars | 5/15 | 3/5 | 4/7 | 141/236 |
| Telangiectasia | 5/11 | 2/4 | 3/5 | 152/222 |
| Internal involvements | ||||
| Oesophagus | 9/12 | 2/4 | 5/5 | 99/172 |
| Lungs | 7/14 | 2/5 | 5/7 | 89/212 |
| Heart | 1/14 | 0/7 | 0/7 | 14/210 |
| Joints | 6/13 | 1/5 | 3/7 | 96/198 |
| Kidneys | 1/15 | 0/5 | 0/7 | 9/236 |
| Coexistence of other connective tissue diseases | ||||
| Sjogren’s syndrome | 11/12 | 5/5 | 1/61-160 | 49/79 |
| Systemic lupus erythematosus | 1/15 | 0/5 | 2/7 | 9/236 |
↵1-160 p < 0.01, compared with patients with Ro52 and Ro60, and those with Ro52 alone, respectively.