LMP2 genotype distribution in the investigated groups. LMP2BB genotypes were compared against LMP2AB and AA genotypes. The significant differences in genotype distribution were between DR4 positive patients with spondyloarthropathy (SpA) compared with DR4 negative patients with SpA (1-150) and between DR4 positive patients with SpA compared with DR4 negative, B27 controls (†) (p < 0.03)
| Subjects | AA | AB | BB | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Number | % | Number | % | Number | % | ||||||
| Controls (n=99) | 8 | 8.1 | 42 | 42.4 | 49 | 49.5 | |||||
| B27 positive controls (n=46) | 3 | 6.5 | 21 | 45.7 | 22 | 47.8 | |||||
| B27 positive controls, DR4 negative (n=38) | 3 | 7.9 | 18 | 47.4 | 17† | 44.4† | |||||
| SpA (n=172) | 12 | 7.0 | 64 | 37.2 | 96 | 55.8 | |||||
| Ankylosing spondylitis (n=141) | 9 | 6.4 | 52 | 36.9 | 80 | 56.7 | |||||
| SpA, without peripheral arthritis and uveitis (n=79) | 6 | 7.6 | 32 | 40.5 | 41 | 51.9 | |||||
| SpA, DR4 negative (n=119) | 10 | 8.4 | 49 | 41.2 | 601-150 | 50.41-150 | |||||
| SpA, DR4 positive (n=53) | 2 | 3.8 | 15 | 28.3 | 361-150 † | 67.91-150 † | |||||
| SpA and peripheral arthritis (n=72) | 5 | 6.9 | 27 | 37.5 | 40 | 55.6 | |||||
| SpA and peripheral arthritis, DR4 negative (n=52) | 5 | 9.6 | 21 | 40.4 | 26 | 50.0 | |||||
| SpA and uveitis (n=46) | 2 | 4.4 | 16 | 34.8 | 28 | 60.9 | |||||
| SpA and uveitis, DR4 negative (n=30) | 2 | 6.7 | 13 | 43.3 | 15 | 50.0 | |||||
| SpA, peripheral arthritis and uveitis (n=25) | 1 | 4.0 | 11 | 44.0 | 13 | 52.0 | |||||
| SpA, peripheral arthritis and uveitis, DR4 negative (n=16) | 1 | 6.3 | 9 | 56.3 | 6 | 37.5 | |||||
↵1-150 p = 0.04; odds ratio 2.08; 99% confidence intervals (0.8, 8.15); π = 30%. † p = 0.03; odds ratio 2.62; 99% confidence intervals (0.78, 8.79); π = 27%.