Clinical measures, subjective MRI scores, and calculated MRI changes for TA (n=9) and TA+Y (n=7) groups
| TA group | TA + Y group | |||||||||||||||||
| Baseline | Week 1 | I | NC | D | p Value | Baseline | Week 4 | I | NC | D | p Value | Week 12 | I | NC | D | p Value | ||
| Clinical score | ||||||||||||||||||
| Pain + stiffness | 9 (1–13) | 3 (0–6) | 6 | 0 | 0 | 0.016 | 9 (6–14) | 4 (1–12) | 7 | 0 | 0 | 0.008 | 12 (2–14) | 3 | 0 | 3 | NS | |
| Soft tissue swell | 1 (1–2) | 1 (0–2) | 4 | 2 | 0 | * | 1 (1–2) | 1 (0–1) | 5 | 2 | 0 | 0.031 | 1 (0–2) | 3 | 3 | 0 | * | |
| Patient opinion | 1 (1–4) | 1 (1–3) | 3 (1–5) | |||||||||||||||
| MRI score | ||||||||||||||||||
| Effusion | 2 (1–3) | 1 (0–2) | 6 | 3 | 0 | 0.016 | 1 (0–3) | 1 (0–2) | 4 | 0 | 3 | NS | 0.5 (0–3) | 3 | 1 | 2 | NS | |
| Synovial mass | 2 (0–3) | 2 (0–3) | 3 | 6 | 0 | * | 2 (1–3) | 1 (0–3) | 3 | 3 | 1 | * | 2 (0–3) | 2 | 2 | 2 | * | |
| Enhancement | 2 (0–2) | 1 (0–2) | 4 | 4 | 0 | * | 2 (1–2) | 2 (0–2) | 3 | 3 | 1 | * | 1.5 (0–3) | 3 | 1 | 2 | NS | |
| Baseline | Week 1 | Change | p Value | Baseline | Week 4 | Change | p Value | Week 12 | Change | p Value | ||||||||
| MRI calculation | ||||||||||||||||||
| Synovial fluid volume (ml) | 30.0 (7,160) | 10.6 (0.2,42.7) | −20.9 (−139,7.4) | 0.021 | 11.4 (0.6,44.8) | 5.2 (1.6,41) | 1.5 (−35,5.5) | NS | 4.0 (2.1,38) | −2.6 (−27,24) | NS | |||||||
| Pannus volume (ml) | 158.0 (30,276) | 151.0 (66,204) | −24.0 (−125,52) | NS | 147 (127,229) | 123 (57,189) | −24 (−125,52) | NS | 136 (66,195) | −66 (−150,60) | NS | |||||||
| % Synovial enhancement | 110.5 (66,415) | 85.0 (28,259) | −50.0 (−156,−5.0) | 0.012 | 104.0 (34,158) | 72.0 (8.0,275) | −22.0 (−84,164) | NS | 131.0 (72,363) | 38 (−27,293) | NS | |||||||
| Max gradient (U/s) | 8.9 (4.4,23) | 3.9 (1.7,22.6) | −3.5 (−6.0,−0.1) | 0.028 | 4.3 (2.2,14) | 7.8 (3.0,16) | 0.6 (−0.1,12.2) | NS | 11.9 (3.6,16.6) | 1.4 (−6.9,13.1) | NS | |||||||
Results are reported as median values (range: min,max). For clinical measures and subjective MRI scores the number of subjects who improved (I), deteriorated (D) or did not change (NC) are also given. Results analysed by Wilcoxon signed rank test. * = trend for improvement but insufficient numbers to calculate. NS = p>0.05.