Table 1

Biodistribution of^99mTc-non-PEG-liposomes, ^99mTc-PEG-liposomes, and ^99mTc-IgG in rats with adjuvant arthritis two, eight, and 24 hours after injection (%ID/g 5 rats/group)

		Non-PEG-liposomes			PEG-liposomes			^99m Tc-IgG
		2 hours	8 hours		24 hours	2 hours		8 hours	24 hours	2 hours	8 hours	24 hours
Blood	0.17 (0.03)	0.07 (0.01)	0.03 (0.01)	4.27 (0.28)	3.49 (0.33)	2.42 (0.33)	2.79 (0.27)	1.19 (0.10)	0.50 (0.09)
Inflamed ankle	0.10 (0.01)	0.11 (0.04)	0.05 (0.01)	0.49 (0.08)	0.77 (0.04)	1.15 (0.18)	0.46 (0.05)	0.44 (0.05)	0.35 (0.03)
Unaffected ankle	0.03 (0.00)	0.03 (0.01)	0.02 (0.00)	0.14 (0.02)	0.14 (0.02)	0.16 (0.02)	0.16 (0.01)	0.11 (0.02)	0.08 (0.01)
Muscle	0.01 (0.00)	0.01 (0.00)	0.00 (0.00)	0.05 (0.01)	0.06 (0.02)	0.04 (0.01)	0.05 (0.01)	0.05 (0.02)	0.02 (0.01)
Bone marrow	0.29 (0.08)	0.25 (0.09)	0.24 (0.07)	0.72 (0.17)	0.83 (0.09)	1.03 (0.16)	0.76 (0.08)	0.56 (0.12)	0.32 (0.05)
Femur	0.08 (0.02)	0.03 (0.01)	0.03 (0.01)	0.16 (0.03)	0.11 (0.02)	0.17 (0.02)	0.20 (0.02)	0.09 (0.02)	0.07 (0.02)
Lung	0.16 (0.05)	0.09 (0.02)	0.07 (0.02)	0.95 (0.12)	1.08 (0.23)	0.70 (0.07)	0.94 (0.22)	0.57 (0.12)	0.27 (0.05)
Spleen	5.01 (1.09)	5.04 (1.21)	4.01 (0.80)	6.15 (0.47)	7.84 (0.95)	11.1 (1.46)	0.87 (0.11)	0.55 (0.09)	0.34 (0.04)
Kidney	3.68 (0.45)	3.56 (0.71)	2.97 (0.43)	1.41 (0.24)	1.73 (0.12)	2.60 (0.36)	7.84 (0.79)	7.80 (0.90)	7.62 (1.29)
Liver	2.65 (0.20)	1.81 (0.36)	1.28 (0.43)	1.16 (0.23)	0.98 (0.21)	0.78 (0.31)	1.24 (0.10)	0.74 (0.07)	0.33 (0.08)
Intestine	0.12 (0.02)	0.05 (0.01)	0.02 (0.00)	0.62 (0.28)	0.71 (0.20)	0.60 (0.04)	0.50 (0.05)	0.25 (0.04)	0.13 (0.02)

IA/UA ratio	2.97 (0.35)	4.97 (2.48)	2.96 (0.54)	3.53 (0.62)	5.58 (1.01)	7.51 (0.91)	2.92 (0.49)	3.9 (0.67)	4.27 (0.65)

Data shown as mean (SD).