Comparison between Whipple’s disease and adult onset Still’s disease
| Whipple’s disease (adapted from6 7) | Adult Still’s disease (adapted from8) | |
|---|---|---|
| Occurrence | Rare | Uncommon |
| Male:female | 8:1 | 1:1 |
| Peak age at onset | 30–60 | 16–35 |
| Mean age at onset | 49 | 30 |
| Ethnicity | Predominantly white | Worldwide |
| Clinical features | ||
| Fever | ||
| Frequency | 10–55% | 96% |
| Type | Usually low grade, intermittent | Usually high spiking once or twice a day |
| Joints | ||
| Arthralgia | >80% | 100% |
| Arthritis | Often transient | Usually persisent or in episodes of >2 weeks |
| Large > small joints | Large > small joints | |
| Usually non-deforming | Deforming in 31% | |
| Radiology | Usually non-erosive | Often erosive and ankylosing eventually9 |
| Others | ||
| Weight loss ⩾10% | 95% | 38% |
| Lymphadenopathy | 50% | 60% |
| Hepatosplenomegaly | 15% | 48% |
| Rash | — | 88% |
| Diarrhoea | 75% | — |
| Adominal pain | 60% | 13% |
| Neutrophilia (15 000) | — | 75% |