PT - JOURNAL ARTICLE AU - Rachel Charlton AU - Amelia Green AU - Gavin Shaddick AU - Julia Snowball AU - Alison Nightingale AU - William Tillett AU - Catherine H Smith AU - Neil McHugh ED - , TI - Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis: a population-based cohort study AID - 10.1136/annrheumdis-2017-212328 DP - 2017 Nov 01 TA - Annals of the Rheumatic Diseases PG - annrheumdis-2017-212328 4099 - http://ard.bmj.com/content/early/2017/11/01/annrheumdis-2017-212328.short 4100 - http://ard.bmj.com/content/early/2017/11/01/annrheumdis-2017-212328.full AB - Objectives To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis.Methods A cohort study using data from the UK Clinical Practice Research Datalink between 1998 and 2014. Patients with incident PsA aged 18–89 years were identified and matched to a cohort of patients with psoriasis and a general population cohort. The incidence of uveitis, all IBD, Crohn’s disease and ulcerative colitis was calculated for each study cohort and adjusted relative risks (RRadj) were calculated using conditional Poisson regression.Results 6783 incident cases of PsA were identified with a median age of 49 years. The risk of uveitis was significantly higher in the PsA cohort than in the general population and psoriasis cohorts (RRadj 3.55, 95% CI 2.21 to 5.70 and RRadj 2.13, 95% CI 1.40 to 3.24, respectively). A significant increase was observed for Crohn’s disease (RRadj 2.96, 95% CI 1.46 to 6.00 and RRadj3.60, 95% CI 1.83 to 7.10) but not for ulcerative colitis (RRadj1.30, 95% CI 0.66 to 2.56 and RRadj0.98, 95% CI 0.50 to 1.92).Conclusions In a primary care-based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn’s disease, but not ulcerative colitis, when compared with the general population and psoriasis controls.