TY - JOUR T1 - The EuroMyositis registry: an international collaborative tool to facilitate myositis research JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis DO - 10.1136/annrheumdis-2017-211868 SP - annrheumdis-2017-211868 AU - James B Lilleker AU - Jiri Vencovsky AU - Guochun Wang AU - Lucy R Wedderburn AU - Louise Pyndt Diederichsen AU - Jens Schmidt AU - Paula Oakley AU - Olivier Benveniste AU - Maria Giovanna Danieli AU - Katalin Danko AU - Nguyen Thi Phuong Thuy AU - Monica Vazquez-Del Mercado AU - Helena Andersson AU - Boel De Paepe AU - Jan L deBleecker AU - Britta Maurer AU - Liza J McCann AU - Nicolo Pipitone AU - Neil McHugh AU - Zoe E Betteridge AU - Paul New AU - Robert G Cooper AU - William E Ollier AU - Janine A Lamb AU - Niels Steen Krogh AU - Ingrid E Lundberg AU - Hector Chinoy A2 - , Y1 - 2017/08/30 UR - http://ard.bmj.com/content/early/2017/08/30/annrheumdis-2017-211868.abstract N2 - Aims The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data.Methods Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated.Results Of 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001).Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001).ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases (‘V’ sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%.Conclusion This large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients. ER -