TY - JOUR T1 - Promoter hypermethylation of the anti-fibrotic gene socs-3 by TGFβ as novel mechanism in the pathogenesis of SSc JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - A26 LP - A26 DO - 10.1136/ard.2010.129601d VL - 69 IS - Suppl 2 AU - Clara Dees AU - Alfiya Akhmetshina AU - Nicole Busch AU - Angelika Horn AU - Johannes Gusinde AU - Astrid Jünge AU - Steffen Gay AU - Oliver Distler AU - Georg Schett AU - Jörg H W Distler Y1 - 2010/03/01 UR - http://ard.bmj.com/content/69/Suppl_2/A26.1.abstract N2 - Tissue fibrosis caused by a pathological activation of systemic sclerosis (SSc) fibroblasts is a major hallmark of SSc. Transforming growth factor beta (TGFβ)is a major mediator of fibrosis and has been identified as key-player in the pathogenesis of SSc. Alterations in DNA methylation and subsequent changes in gene transcription have been implicated in the pathogenesis of SSc. The aim of the present study was to investigate whether TGFβ induces DNA methylation. The methylation status of suppressor of cytokine … ER -