TY - JOUR T1 - Detection of genuine anti-citrullinated protein antibodies in mice reveals their presence in BALB/c but not DBA/1 and SJL mice hyperimmunised with citrullinated collagen JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - A5 LP - A5 DO - 10.1136/ard.2010.129577l VL - 69 IS - Suppl 2 AU - T Cantaert AU - C A Teitsma AU - P P Tak AU - D L Baeten Y1 - 2010/03/01 UR - http://ard.bmj.com/content/69/Suppl_2/A5.2.abstract N2 - Antibodies against citrullinated proteins (ACPA) occur in 60–70% of all rheumatoid arthritis (RA) patients with a specificity of 95%. The role of the immune response against citrullinated proteins in the pathophysiology of RA remains unknown, because studies in experimental models yielded contrasting results. It is unclear whether mice develop antibodies crucially dependent on citrullination of the epitope. The authors aimed to develop a reliable method to detect ACPA in mice and to assess the development of ACPA in different mouse … ER -