TY - JOUR T1 - Loss of integrin α2β1 reduces tumour necrosis factor-dependent inflammatory cartilage destruction and matrix metalloproteinase expression through modulating extracellular signal-regulated kinase JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - A22 LP - A23 DO - 10.1136/ard.2010.129593r VL - 69 IS - Suppl 2 AU - M A Peters AU - S Strietholt AU - D Wendholt AU - S Frank AU - A Korb AU - G Kollias AU - B Eckes AU - T Pap Y1 - 2010/03/01 UR - http://ard.bmj.com/content/69/Suppl_2/A22.2.abstract N2 - Integrins are the main receptors for cell-matrix interactions and integrin signalling is critical for a variety of cellular functions such as adhesion, cell spreading and inflammatory responses. α2β1 integrin functions as a major receptor for type I collagen on a number of different cells, including fibroblasts and inflammatory cells. Although α2-deficient mice appear normal apart from mild platelet dysfunction, it was shown that α2β1 integrin contributes to the induction of matrix metalloproteinases (MMPs) in tissue remodelling. Based on the hypothesis … ER -