RT Journal Article SR Electronic T1 No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain JF Annals of the Rheumatic Diseases JO Ann Rheum Dis FD BMJ Publishing Group Ltd and European League Against Rheumatism SP 2009 OP 2012 DO 10.1136/ard.2009.126086 VO 69 IS 11 A1 Barbara I Nicholl A1 Kate L Holliday A1 Gary J Macfarlane A1 Wendy Thomson A1 Kelly A Davies A1 Terence W O'Neill A1 Gyorgy Bartfai A1 Steven Boonen A1 Felipe Casanueva A1 Joseph D Finn A1 Gianni Forti A1 Aleksander Giwercman A1 Ilpo T Huhtaniemi A1 Krzysztof Kula A1 Margus Punab A1 Alan J Silman A1 Dirk Vanderschueren A1 Frederick C W Wu A1 John McBeth A1 European Male Ageing Study Group YR 2010 UL http://ard.bmj.com/content/69/11/2009.abstract AB Objectives The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) ‘pain sensitivity’ haplotypes and chronic widespread pain (CWP) in two distinct cohorts. Methods Cases of CWP and controls free of pain were selected from two population-based studies: the Epidemiology of Functional Disorders study (EPIFUND) (UK) and the European Male Ageing Study (European). The number of cases and controls were 164 and 172, and 204 and 935, respectively. Identical American College of Rheumatology criteria were used in both studies to ascertain CWP status. The EPIFUND study had three time points and cases were classified as subjects with CWP at two or three time points and controls as those free of pain at all three time points. Four single nucleotide polymorphisms (SNP): rs6269, rs4633, rs4818 and rs4680 (V158M) were genotyped using Sequenom technology. Allele and genotype frequencies were compared and haplotype analysis was conducted using PLINK software. Results No differences in allele or genotype frequencies for any of the four SNP were observed between cases and controls for either cohort. Haplotype analysis also showed no difference in the frequency of haplotypes between cases and controls. Conclusions There was no evidence of association between the COMT ‘pain sensitivity’ haplotypes and CWP in two population-based cohorts.