RT Journal Article
SR Electronic
T1 Prevalence and factors associated with left ventricular dysfunction in the EULAR Scleroderma Trial and Research group (EUSTAR) database of patients with systemic sclerosis
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 218
OP 221
DO 10.1136/ard.2008.103382
VO 69
IS 01
A1 Y Allanore
A1 C Meune
A1 M C Vonk
A1 P Airo
A1 E Hachulla
A1 P Caramaschi
A1 G Riemekasten
A1 F Cozzi
A1 L Beretta
A1 C T Derk
A1 A Komócsi
A1 D Farge
A1 A Balbir
A1 V Riccieri
A1 O Distler
A1 A Chialà
A1 N Del Papa
A1 K Pasalic Simic
A1 M Ghio
A1 B Stamenkovic
A1 S Rednic
A1 N Host
A1 R Pellerito
A1 E Zegers
A1 A Kahan
A1 U A Walker
A1 M Matucci-Cerinic
YR 2010
UL http://ard.bmj.com/content/69/01/218.abstract
AB Objectives: To measure the prevalence of, and factors associated with, left ventricular (LV) dysfunction in systemic sclerosis (SSc).Methods: The EUSTAR database was first searched. A case-control study of a patient subset was then performed to further identify independent factors associated with LV dysfunction by simple and multiple regression.Results: Of 7073 patients, 383 (5.4%) had an LV ejection fraction (EF) of <55%. By multiple regression analysis, age, sex, diffuse cutaneous disease, disease duration, digital ulcerations, renal and muscle involvement, disease activity score, pulmonary fibrosis and pulmonary arterial hypertension were associated with LV dysfunction. In the second phase, 129 patients with SSc with LVEF <55% were compared with 256 patients with SSc with normal LVEF. Male sex (OR 3.48; 95% CI 1.74 to 6.98), age (OR 1.03; 95% CI 1.01 to 1.06), digital ulcerations (OR 1.91; 95% CI 1.05 to 3.50), myositis (OR 2.88; 95% CI 1.15 to 7.19) and use of calcium channel blockers (OR 0.41; 95% CI 0.22 to 0.74) were independent factors associated with LV dysfunction.Conclusion: The prevalence of LV dysfunction in SSc is 5.4%. Age, male gender, digital ulcerations, myositis and lung involvement are independently associated with an increased prevalence of LV dysfunction. Conversely, the use of calcium channel blockers may be protective.