RT Journal Article
SR Electronic
T1 Enhancement of urate solubility by connective tissue. II. Inhibition of sodium urate crystallisation by cation exchange.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 467
OP 470
DO 10.1136/ard.38.5.467
VO 38
IS 5
A1 E Perricone
A1 K D Brandt
YR 1979
UL http://ard.bmj.com/content/38/5/467.abstract
AB The urate concentration of the supernatant was greater after supersaturated solutions of sodium urate were incubated in a suspension of CM-Sephadex C-25 than in one of Sephadex G-25. The supernatant urate concentration was greater when the CM-Sephadex had been equilibrated with potassium than with sodium. The results are analogous with those obtained in studies of urate solubility in proteoglycan solutions. They are consistent with the Donnan effect and the hypothesis that the glycosaminoglycans within the proteoglycan molecule function as cation exchangers which, when charged with potassium, exchange with the sodium of the urate molecule, leading to formation of highly soluble potassium urate.