Studies with radiolabelled serum amyloid P component provide evidence for turnover and regression of amyloid deposits in vivo

Clin Sci (Lond). 1994 Sep;87(3):289-95. doi: 10.1042/cs0870289.

Abstract

1. Quantitative scintigraphic and turnover studies, utilizing the specific binding affinity of serum amyloid P component for amyloid fibrils, have been developed as a tool for evaluating amyloid deposits in vivo. 2. Serial studies in over 300 patients have shown characteristic, diagnostic tissue distributions of amyloid in different types of amyloidosis. There is generally a poor correlation between quantity of amyloid and associated organ dysfunction. 3. Contrary to previous expectations, regression of amyloid has been demonstrated systematically for the first time: AA, AL and variant transthyretin-associated amyloid deposits often regress rapidly, and sometimes completely, if the supply of fibril protein precursors is substantially reduced.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyloid / metabolism*
  • Amyloidosis / diagnostic imaging
  • Amyloidosis / metabolism*
  • Animals
  • Humans
  • Iodine Radioisotopes
  • Radionuclide Imaging
  • Serum Amyloid P-Component / pharmacokinetics*

Substances

  • Amyloid
  • Iodine Radioisotopes
  • Serum Amyloid P-Component