Abstract
We describe a man treated with cyclophosphamide and prednisone for Wegener's granulomatosis who developed biopsy proven progressive multifocal leukoencephalopathy (PML). Upon discontinuation of immunosuppression he made a dramatic recovery. As immunosuppressant use is increasing we draw attention to this potentially fatal, but reversible neurologic disease.
MeSH terms
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Brain / diagnostic imaging
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Brain / pathology
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Brain / virology
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Cyclophosphamide / adverse effects*
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Granulomatosis with Polyangiitis / drug therapy*
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Humans
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Immunosuppressive Agents / adverse effects*
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JC Virus / isolation & purification
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Leukoencephalopathy, Progressive Multifocal / etiology*
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Leukoencephalopathy, Progressive Multifocal / pathology
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Male
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Middle Aged
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Radiography
Substances
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Immunosuppressive Agents
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Cyclophosphamide