Progressive multifocal leukoencephalopathy complicating treatment for Wegener's granulomatosis

J Rheumatol. 1995 Aug;22(8):1593-5.

Abstract

We describe a man treated with cyclophosphamide and prednisone for Wegener's granulomatosis who developed biopsy proven progressive multifocal leukoencephalopathy (PML). Upon discontinuation of immunosuppression he made a dramatic recovery. As immunosuppressant use is increasing we draw attention to this potentially fatal, but reversible neurologic disease.

Publication types

  • Case Reports

MeSH terms

  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain / virology
  • Cyclophosphamide / adverse effects*
  • Granulomatosis with Polyangiitis / drug therapy*
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • JC Virus / isolation & purification
  • Leukoencephalopathy, Progressive Multifocal / etiology*
  • Leukoencephalopathy, Progressive Multifocal / pathology
  • Male
  • Middle Aged
  • Radiography

Substances

  • Immunosuppressive Agents
  • Cyclophosphamide