Histologic findings in siblings with acute sarcoid arthritis: association with the B8,DR3 phenotype

J Rheumatol. 1986 Jun;13(3):593-7.

Abstract

Three siblings with acute sarcoid arthritis and hilar adenopathy on chest radiograph (Löfgren's syndrome) are presented. Synovianalysis from 2 of 3 showed a predominance of mononuclear cells, and synovial biopsies from 2 of the 3 showed a mild inflammatory synovitis. All 3 siblings exhibited the B8,DR3 phenotype, and HLA testing of 8 prior cases identified at this institution showed the B8,DR3 phenotype in 6 of 8 patients with the 2 other patients exhibiting either B8 or DR3 alone. We confirm an earlier report that the B8,DR3 phenotype identifies a group of patients who are more likely to have acute sarcoid arthritis and hilar adenopathy without developing chronic disease.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Adult
  • Arthritis / genetics*
  • Arthritis / pathology
  • Female
  • Genotype
  • HLA Antigens / genetics*
  • HLA-B8 Antigen
  • HLA-DR3 Antigen
  • Histocompatibility Antigens Class II / genetics*
  • Humans
  • Male
  • Microscopy, Electron
  • Pedigree
  • Phenotype
  • Sarcoidosis / genetics*
  • Sarcoidosis / pathology
  • Synovial Fluid / analysis
  • Synovial Membrane / pathology
  • Synovial Membrane / ultrastructure

Substances

  • HLA Antigens
  • HLA-B8 Antigen
  • HLA-DR3 Antigen
  • Histocompatibility Antigens Class II