Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis

Brigit A de Jong; Rudi G J Westendorp; Joyce Eskdale; Bernard M J Uitdehaag; Tom W J Huizinga

doi:10.1016/s0198-8859(02)00369-5

Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis

Hum Immunol. 2002 Apr;63(4):281-5. doi: 10.1016/s0198-8859(02)00369-5.

Authors

Brigit A de Jong¹, Rudi G J Westendorp, Joyce Eskdale, Bernard M J Uitdehaag, Tom W J Huizinga

Affiliation

¹ Department of Clinical Epidemiology, University of Glasgow, Scotland, United Kingdom.

PMID: 12039409
DOI: 10.1016/s0198-8859(02)00369-5

Abstract

Interleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune encephalomyelitis and the outcome of multiple sclerosis (MS). Here, we report that a G to A polymorphism in the IL-10 promoter at position -2849 is significantly associated with low IL-10 production. The frequency of this polymorphism is lower among patients with primary progressive compared with patients with relapse-onset MS and control persons.

MeSH terms

Adult
Disease Susceptibility
Female
HLA-DR2 Antigen / immunology
Humans
Interleukin-10 / biosynthesis
Interleukin-10 / genetics*
Male
Middle Aged
Multiple Sclerosis, Chronic Progressive / genetics*
Multiple Sclerosis, Chronic Progressive / immunology
Multiple Sclerosis, Relapsing-Remitting / genetics*
Multiple Sclerosis, Relapsing-Remitting / immunology
Polymorphism, Genetic*

Substances

HLA-DR2 Antigen
Interleukin-10