Abstract
Recently, three new family members of the tumor necrosis factor (TNF) ligand and receptor signaling system that play a critical role in the regulation of bone resorption have been identified and cloned. These also have been shown to play an important role in regulating the immune system. A proliferation of synonyms for these molecules has led to miscommunication and redundancy. To resolve this, the President of the American Society for Bone and Mineral Research (ASBMR) appointed a special committee to recommend a standard nomenclature. After considerable deliberation and after vetting by workers in the field, the Committee recommends the names of receptor activator of NF-kappaB (RANK) for the membrane receptor, RANK ligand (RANKL) for the ligand, and osteoprotegerin (OPG) for the decoy receptor.
MeSH terms
-
Bone Resorption / metabolism
-
Carrier Proteins* / metabolism
-
GPI-Linked Proteins
-
Glycoproteins* / metabolism
-
Humans
-
Lymphokines* / metabolism
-
Membrane Glycoproteins* / metabolism
-
Osteoclasts / metabolism
-
Osteoprotegerin
-
RANK Ligand
-
Receptor Activator of Nuclear Factor-kappa B
-
Receptors, Cytoplasmic and Nuclear* / metabolism
-
Receptors, Tumor Necrosis Factor* / metabolism
-
Receptors, Tumor Necrosis Factor, Member 10c
-
Terminology as Topic*
-
Tumor Necrosis Factor Decoy Receptors
-
Tumor Necrosis Factor-alpha / classification*
Substances
-
Carrier Proteins
-
GPI-Linked Proteins
-
Glycoproteins
-
Lymphokines
-
Membrane Glycoproteins
-
Osteoprotegerin
-
RANK Ligand
-
Receptor Activator of Nuclear Factor-kappa B
-
Receptors, Cytoplasmic and Nuclear
-
Receptors, Tumor Necrosis Factor
-
Receptors, Tumor Necrosis Factor, Member 10c
-
TNFRSF10C protein, human
-
TNFRSF11A protein, human
-
TNFRSF11B protein, human
-
TNFSF11 protein, human
-
Tumor Necrosis Factor Decoy Receptors
-
Tumor Necrosis Factor-alpha
-
osteoclast activating factor