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Changes in patterns of fatness in adult men in relation to serum indices of cardiovascular risk: the Normative Aging Study

International Journal of Obesity volume 24, pages 1369–1378 (2000)Cite this article

Abstract

BACKGROUND: Overweight and/or excessive weight gain, as well as changes in central fat deposition, have been implicated in increased incidence of coronary disease and type 2 diabetes.

OBJECTIVE: We related adiposity (BMI, kg/m2, and waist circumference, WC, cm) to biochemical risk factors (cholesterol, triglyceride and glucose concentrations) for cardiovascular disease and diabetes.

DESIGN: Associations were examined both cross-sectionally and longitudinally, among 867 men enrolled in the Normative Aging Study (NAS). We included all participants with complete anthropometric and clinical data at both enrollment (average age 45 y) and after approximately 15 y of follow-up (average age 60 y). We used multiple linear regression analysis to test relationships between body fatness and change in body fatness and the biochemical indices.

RESULTS: In adulthood, concurrent BMI and waist circumference related significantly to triglyceride and glucose concentrations and to 2 h glucose responses at two time points. Measures of fatness 15 y earlier were also predictive of later triglyceride and glucose measures. When included together, BMI, but not WC, remained independently associated with triglycerides at both time points, while WC, but not BMI, remained significantly associated with fasting glucose concentrations and glucose response at the follow-up observation. In contrast, gains in weight and abdominal fat from entry to follow-up related more strongly to serum cholesterol concentrations than did concurrent measures.

CONCLUSION: Attained weight, weight gain, and location of weight contribute differentially to these indices of cardiovascular and diabetes risk.

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Acknowledgements

Supported in part by funds from the USDA Agricultural Research Service under contract no. 53-3K06-5-10. The Normative Aging Study is supported by the Cooperative Studies Program of the Department of Veterans Affairs and is a research component of the Massachusetts Veterans Epidemiology and Information Center (MAVERIC). Special thanks to Bonnie Myers for assistance with data analysis and Dr Gerard Dallal for statistical consultation. Portions of this paper were presented at the Federation of the American Societies of Experimental Biology, 1995.

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Authors and Affiliations

  1. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, 02111, MA, USA

    JA Grinker, KL Tucker & D Rush

  2. Normative Aging Study, Department of Veterans Affairs, Outpatient Clinic, Boston, MA

    PS Vokonas

  3. Section of Preventive Medicine and Epidemiology and the Evans Memorial Department of Clinical Research, Department of Medicine, Boston University School of Medicine, Boston, MA, USA

    PS Vokonas

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Grinker, J., Tucker, K., Vokonas, P. et al. Changes in patterns of fatness in adult men in relation to serum indices of cardiovascular risk: the Normative Aging Study. Int J Obes 24, 1369–1378 (2000). https://doi.org/10.1038/sj.ijo.0801397

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