Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Rheumatoid arthritis association at 6q23

Abstract

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−5 − 5 × 10−7 in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 × 10−8) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-α–induced protein 3 (TNFAIP3).

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. The Wellcome Trust Case Control Consortium. Nature 447, 661–678 (2007).

  2. Steer, S., Lad, B., Grumley, J.A., Kingsley, G.H. & Fisher, S.A. Arthritis Rheum. 52, 358–360 (2005).

    Article  CAS  Google Scholar 

  3. Hinks, A. et al. Arthritis Rheum. 52, 1694–1699 (2005).

    Article  CAS  Google Scholar 

  4. Harrison, P., Pointon, J.J., Farrar, C., Brown, M.A. & Wordsworth, B.P. Rheumatology (Oxford) 45, 1009–1011 (2006).

    Article  CAS  Google Scholar 

  5. Huizinga, T.W. et al. Arthritis Rheum. 52, 3433–3438 (2005).

    Article  CAS  Google Scholar 

  6. Klareskog, L. et al. Arthritis Rheum. 54, 38–46 (2006).

    Article  CAS  Google Scholar 

  7. Zheng, D. et al. Genome Res. 17, 839–851 (2007).

    Article  CAS  Google Scholar 

  8. Filippi, A. et al. Proc. Natl. Acad. Sci. USA 102, 4377–4382 (2005).

    Article  CAS  Google Scholar 

  9. Boone, D.L. et al. Nat. Immunol. 5, 1052–1060 (2004).

    Article  CAS  Google Scholar 

  10. Wertz, I.E. et al. Nature 430, 694–699 (2004).

    Article  CAS  Google Scholar 

  11. Lee, E.G. et al. Science 289, 2350–2354 (2000).

    Article  CAS  Google Scholar 

  12. Lowe, C.E. et al. Nat. Genet. 39, 1074–1082 (2007).

    Article  CAS  Google Scholar 

  13. Hafler, D.A. et al. N. Engl. J. Med. 357, 851–862 (2007).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Funding for this study was provided by the Arthritis Research Campaign (arc). We thank the Wellcome Trust for funding the WTCCC. We would also like to acknowledge the National Health Service (NHS) Research and Development Support Fund for Guy's and St Thomas' and Lewisham NHS Trusts. We acknowledge use of DNA from the British 1958 Birth Cohort collection, funded by the Medical Research Council grant G0000934 and the Wellcome Trust grant 068545/Z/02. IT support was provided by M. Lay, and technical support was provided by P. Gilbert, B. Lad and S.G. Martin. Nursing support was provided by J. Grumley, J. Shotton and C. Farrar.

Author information

Authors and Affiliations

Authors

Consortia

Contributions

W.T., A.B., X.K., S.E. and J.W. participated in the conception, design and coordination of the study, data analysis and writing of the manuscript. D.S., S.H., I.N.B., A.G.W., I.M., A.M., P.E., YEAR Consortium, A.C., S.S., L.H., D.M.R., P.W., P.H. and D.S. recruited study subjects and extracted phenotype data. S.E., A.H. and J.B. performed the genotyping. X.K. undertook the statistical analysis. R.D. contributed to preparation of the manuscript. WTCCC provided the initial data for rheumatoid arthritis cases and controls. Members of the WTCCC and YEAR consortium are listed in the Supplementary Note.

Corresponding author

Correspondence to Jane Worthington.

Additional information

For full lists of members of these consortia, see Supplementary Note

For full lists of members of these consortia, see Supplementary Note

Supplementary information

Supplementary Text and Figures

Supplementary Tables 1–5, Supplementary Figure 1, Supplementary Methods, Supplementary Note (PDF 154 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thomson, W., Barton, A., Ke, X. et al. Rheumatoid arthritis association at 6q23. Nat Genet 39, 1431–1433 (2007). https://doi.org/10.1038/ng.2007.32

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.2007.32

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing