Effect of cytokines on neuronal excitability

doi:10.1016/j.neulet.2008.03.052

Neuroscience Letters

Volume 437, Issue 3, 6 June 2008, Pages 188-193

https://doi.org/10.1016/j.neulet.2008.03.052 Get rights and content

Abstract

Numerous studies have shown that proinflammatory cytokines induce or facilitate pain and hyperalgesia in the presence of inflammation, injury to the nervous system or cancer. Besides acting as inflammatory mediators, increasing evidence indicates that cytokines may also specifically interact with receptor and ion channels regulating neuronal excitability, synaptic plasticity and injury under both physiological and pathological conditions. Here we summarize findings on two prototypical proinflammatory cytokines, tumor-necrosis factor-α and interleukin-1β, and their effects on neuronal excitability and ion channels with special regards to pain and hyperalgesia.

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Effect of cytokines on neuronal excitability

Abstract

Brain Res.

Eur. J. Pharmacol.

Pain

Neurosci. Lett.

Brain Res.

Mol Cell. Neurosci.

Brain Res.

Pain

Pain

Eur. J. Pharmacol.

Cell Signal

Neuroscience

Neurobiol. Aging

Biochem. Biophys. Res. Commun.

Exp. Neurol.

Brain Res. Bull.

Eur. J. Pharmacol.

Neuropharmacology

Brain Res.

Eur. J. Pain

J. Biol. Chem.

Neurosci. Lett.

Neurosci. Lett.

Brain Res.

Neuroscience

Neuroscience

FEBS Lett.

Int. Rev. Neurobiol.

Neurosci. Lett.

Pain

Brain Res.

Brain Res.

Neurosci. Lett.

Control of synaptic strength by glial TNF-alpha

Science

Effect of recombinant human interleukin-1 beta on K+ channels of mice bone marrow stromal cells

Sheng Li Xue Bao

Reduction of excitation by interleukin-1 beta in rat neocortical slices visualized using infrared-darkfield videomicroscopy

Neuroreport

Effect of recombinant human interleukin-1 beta on K⁺ channels of mice bone marrow stromal cells