Original articleClinical and Laboratory Characteristics and Long-Term Outcome of Pediatric Systemic Lupus Erythematosus: A Longitudinal Study
Section snippets
Methods
The study population comprised an inception cohort of all 256 patients with pSLE diagnosed at the Hospital for Sick Children, Toronto between March 1982 and January 2005. All patients met at least 4 of the American College of Rheumatology (ACR) classification criteria for SLE.21 All patients were followed in the pSLE clinic, and beginning in 1988, all data were prospectively collected and entered into a dedicated SLE database. Data obtained before 1988 was retrospectively obtained from chart
Demographic Data
The cohort consisted of 256 patients (211 females and 45 males [ratio, 4.7:1]), with a mean age at diagnosis of 13.1 ± 3.17 years (range, 3 to 18 years). The mean follow-up period was 3.5 ± 3 years (range, 0 to 16.2 years). A total of 81 of the 188 (43%) patients with Tanner stage information at diagnosis were diagnosed with SLE before puberty. There was no statistically significant difference in the female:male ratio of patients diagnosed prepubertally and that in those diagnosed
Discussion
SLE is a chronic autoimmune disease that affects both children and adults, with onset in childhood in approximately 20% of cases. Despite numerous reports of SLE in adults, in the past 10 years there have been fewer than 15 reports on the clinical and laboratory features of patients with onset of SLE in the pediatric age group and no large single-center inception cohort.3, 5, 6, 10, 14, 15, 29, 30, 31, 32 Although adult studies report a female:male ratio of approximately 10:1,33, 34, 35 in our
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