Notch signaling: direct or what?
References (67)
- et al.
Mouse DII3:a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo
Development
(1997) - et al.
Jagged: a mammalian ligand that activates Notch1
Cell
(1995) - et al.
Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
Development
(1996) - et al.
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
Immunity
(1998) Notch in vertebrates
Curr Opin Genet Dev
(1997)- et al.
Neurogenic and proneural genes control cell fate specification in the Drosophila endoderm
Development
(1995) - et al.
Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate
J Cell Biol
(1995) - et al.
Signalling downstream of activated mammalian Notch
Nature
(1995) - et al.
Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
Mol Cell Biol
(1996) - et al.
Epstein-Barr Virus Immortalization: Notch2 interacts with CBF1 and blocks differentiation
J Virol
(1997)
SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling
Development
Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation
Genes Dev
Limb development:marginal fringe benefits
Curr Biol
Secreted fringe-like signaling molecules may be glycosyltransferases [letter]
Cell
A dominant-negative form of Serrate acts as a general antagonist of Notch activation
Development
The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands
Development
Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos
Curr Biol
Conservation of the Notch signalling pathway in mammalian neurogenesis
Development
Regulation of neuronal diversity in the Xenopus retina by Delta signalling
Nature
Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina
Curr Biol
Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis
Development
Regulation of neuronal specification in the zebrafish spinal cord by Delta function
Development
Neurogenic genes and vertebrate neurogenesis
Curr Opin Neurobiol
Notch signaling in vertebrate development and disease
Mol Cell Neurosci
The intracellular domain of mouse Notch:a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
Development
An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
Development
The ins and outs of notch signaling
Mol Cell Neurosci
Inhibition of granulocytic differentiation by mNotch1
Proc Natl Acad Sci USA
Notch1 and Notch2 inhibit myeloid differentiation in respnse to different cytokines
Mol Cell Biol
The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs:control of cell proliferation
Development
Proneural and neurogenic genes control specification and morphogenesis of stomatogastric nerve cell precursors in Drosophila
Dev Biol
Expression of constitutively active Notch arrests follicle cells at a precursor stage during Drosophila oogenesis and disrupts the anterior-posterior axis of the oocyte
Development
Mouse Serrate-1 [Jagged-1]: Expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4
Development
Cited by (92)
The role of endothelial cell–pericyte interactions in vascularization and diseases
2024, Journal of Advanced ResearchWnt5a controls notch1 signaling through CaMKII -mediated degradation of the SMRT corepressor protein
2012, Journal of Biological ChemistryDual regulation of Notch1 signaling pathway by adaptor protein Fe65
2012, Journal of Biological ChemistryCitation Excerpt :Notch is a single-pass type I transmembrane receptor that performs a key role in the determination of cell fate, differentiation, cell proliferation, cell survival, and cell death (1–4).
Up-regulated expression of Notch1 and Jagged1 in human colon adenocarcinoma
2011, Pathologie BiologieCitation Excerpt :Notch receptors (Notch 1–4) and two groups of ligands, Jagged (Jagged1, 2) and Delta-like (Dll1, 3, 4), are crucial for many types of cell fate determination in a wide range of organisms [1]. Interactions of Notch receptors and its membrane-associated ligands in bordering cells can activate Notch signaling [2]. During maturation, Notch polypeptide precursors are cleaved just outside their transmembrane domain to produce an extracellular subunit (NEC) and a transmembrane subunit (NTM).
The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase
2011, Experimental Cell ResearchCitation Excerpt :The Notch1 receptor performs a crucial role in cell fate decisions, cell growth, differentiation, and proliferation [1–4].
Coordinating the timing of cardiac precursor development during gastrulation: A new role for Notch signaling
2009, Developmental Biology