Vasculitides in hairy cell leukemia

https://doi.org/10.1016/S0049-0172(95)80026-3Get rights and content

Abstract

Forty-two cases of vasculitis coincident with hairy cell leukemia (HCL) havebeen reported, of which 17 had panarteritis nodosa (PAN), 21 had cutaneous leukocytoclastic vasculitis (LCV), and 4 had vessel wall infiltration by hairy cells. PAN generally occurred after the diagnosis of HCL, splenectomy, and infection. HBs antigen was detected in 3 of 12 patients tested, whereas immune complexes were positive in 3 of 4 patients tested. LCV was often preceded by infection and was frequently detected before HCL. Serum immunoglobulin levels were generally elevated when measured. Cryoglobulins, complement, rheumatoid factor, and antinuclear antibodies showed no clear association with vasculitis in HCL. These reports suggest a role for infection and splenectomy as contributing factors to vasculitis.

References (48)

  • KlimaM. et al.

    Hairy cell leukemia associated with focal vascular damage

    Hum Pathol

    (1984)
  • GolombH. et al.

    Hairy cell leukemia: A clinical review based on 71 cases

    Ann Intern Med

    (1978)
  • FlandrinG. et al.

    Hairy cell leukemia: Clinical presentation and follow-up of 211 patients

    Semin Oncol

    (1984)
  • BouzaC. et al.

    Infections in hairy-cell leukemia

    Blood

    (1978)
  • StewartD.J. et al.

    Infections in hairy-cell leukemia

    Cancer

    (1981)
  • GolombH.M. et al.

    Infectious complications in 127 patients with hairy-cell leukemia

    Am J Hematol

    (1984)
  • SeshadriR.S. et al.

    Leukemic reficuloendotheliosis: A failure of monocyte production

    N Engl J Med

    (1976)
  • BraylanR.C. et al.

    Structural and functional properties of the “hairy cells” of leukemic reticuloendotheliosis

    Cancer

    (1978)
  • WormanC.P. et al.

    The nature of hairy cells-A study with a panel of monoclonal antibodies

    Scand J Haematol

    (1983)
  • MeloJ.V. et al.

    The membrane phenotype of hairy cell leukemia. A study with monoclonal antibodies

    Semin Oncol

    (1984)
  • KorsmeyerS.J. et al.

    Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia

  • SaxonA. et al.

    T-lymphocyte variant of hairy-cell leukemia

    Ann Intern Med

    (1978)
  • PopeA. et al.

    Hairy cell leukemia and vasculitis

    J Rheumatol

    (1980)
  • LePogampP. et al.

    Hairy cell leukemia and polyarteritis nodosa

    J Rheumatol

    (1982)
  • Cited by (108)

    • Polyarteritis nodosa: State of the art

      2022, Revue du Rhumatisme (Edition Francaise)
    • Cutaneous polyarteritis nodosa presenting as a paraneoplastic phenomenon in chronic myelogenous leukemia

      2021, JAAD Case Reports
      Citation Excerpt :

      Given the resolution of cutaneous lesions with the imatinib treatment, we believe this case to be an interesting presentation of paraneoplastic cPAN. A relationship between vasculitides and malignancy is well established in the literature1,4,6-8; however, there is a paucity of information available on cPAN presenting as a paraneoplastic phenomenon. Although paraneoplastic cPAN is not readily reported in the literature, there have been reports of paraneoplastic systemic PAN in association with hematologic malignancies.

    • Treatment-Induced Aggravation of Vasculitis in Hairy-Cell Leukemia

      2021, Clinical Lymphoma, Myeloma and Leukemia
    View all citing articles on Scopus
    View full text