ArticleRole of hylan G-F 20 in treatment of osteoarthritis of the hip joint1
Section snippets
Methods
Twenty-five osteoarthritic hip joints in 22 patients were selected for study from the patient population at the rehabilitation clinic at our institution from 1998 to 2000. The demographics included 14 men and 11 women, with a mean age of 56.4 years (range, 39–72y). Inclusion criteria were demonstration of hip OA on plain radiography and magnetic resonance imaging (MRI) and failure of all conservative methods, including physical therapy, anti-inflammatory medications, and fluoroscopically guided
Results
The mean AAOS Lower Limb Core Scale score improved from a preinjection mean of 44.2 (range, 29.1–57.2) to a follow-up mean of 86.1 (range, 71.3–99) (P<.05). Mean visual numeric pain score improved from a preinjection mean of 8.7 (range, 6.4–10) to a follow-up mean of 2.3 (range, 0–7.2). The overall success rate was 84%.
In patients with mild to moderate OA, the mean pain score decreased from a preinjection value of 7.8 to a follow-up value of 1.7. The success rate was 90.5%.
In patients with
Discussion
Hyaluronic acid is an integral part of the connective tissue system. In synovial joints, it forms an important component of the synovial fluid, which contributes to its viscosity, protection of the superficial layer of articular cartilage, and mechanical shock absorption.5
These properties led to the favorable results of intra-articular injections of hyaluronic acid in osteoarthritic knees.2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 Results of hyaluronic acid substitutes like hylan G-F 20 have been quite
Conclusion
Hyaluronic acid compounds such as hylan G-F 20 may benefit select patients with mild to moderate OA of the hip joint, when combined with a structured exercise regimen. More studies, including randomized controlled trials, are required to further substantiate the efficacy of this form of treatment.
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Cited by (51)
Is Intra-Articular Hyaluronic Acid Effective in Treating Osteoarthritis of the Hip Joint?
2015, Journal of ArthroplastyCitation Excerpt :Therefore, orthopaedic surgeons, payors and patients are quite interested in not only the magnitude of the pain relief but the duration of the pain relief associated with the injection. Overall four studies [3,10,15,23] assessed patients for less than three months and both six month (six studies) [4,8,16,17,19,21] and one year (three studies) [20,22,24] follow-up were less frequent. These studies did not assess cost-effectiveness.
Conservative Management of Hip Pain
2012, Disease-a-MonthIntra-articular injections in hip osteoarthritis: Corticosteroids, hyaluronan
2009, Revue du Rhumatisme (Edition Francaise)Viscosupplementation for hip osteoarthritis: Does systematic review of patient-reported outcome measures support use?
2020, Journal of OrthopaedicsCitation Excerpt :The authors found significantly lower LI scores for the HA cohort at all follow-up intervals (Table 4). A visual analog scale (VAS) measured patient reported pain in 29 studies.19–24,26–31,33–48 All studies indicated that VAS scores were reduced following HA administration.
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