Regular ArticleCloning, Characterization, and the Complete 56.8-Kilobase DNA Sequence of the Human NOTCH4 Gene☆,☆☆
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Cited by (38)
Regulation of Hematopoietic Stem Cell Dynamics by Molecular Niche Signaling
2017, Biology and Engineering of Stem Cell NichesNotch4 reveals a novel mechanism regulating Notch signal transduction
2014, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :It is interesting to note that Notch4 expression is under the transcriptional control of canonical Notch signalling. The Notch4 promoter contains CSL binding sites [84] and Notch4 expression is upregulated by transfection with Notch ICD constructs [40,76]. Thus NOTCH4 may serve to attenuate NOTCH1 signalling in a negative feedback loop in a similar manner to the Notch target Nrarp [33,85].
Genetic evidence for the involvement of NOTCH4 in rheumatoid arthritis and alopecia areata
2013, Immunology LettersCitation Excerpt :To date, four Notch receptors (Notch 1–4) and five of their ligands (Delta-like 1, 3, 4 and Jagged 1, 2) have been identified, each of which is located on different chromosome in the human genome [1]. The NOTCH4 gene lies at the centromeric end of MHC class III region approximately 335 kb telomeric of the DRB1 locus [2], and contains 30 exons spanning 56.8 kb of DNA [3]. Protein encoded by this gene is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer.
Investigation of NOTCH4 coding region polymorphisms in sporadic inclusion body myositis
2012, Journal of NeuroimmunologyCitation Excerpt :Genes involved in regulating cellular differentiation, such as NOTCH4, are thus candidates for playing a role in this aspect of sIBM pathology. Given the expression of NOTCH4 in skeletal muscle (Li et al., 1998) and its role in regulating cellular differentiation, NOTCH4 variants could play a part in the pathogenesis of sIBM by inhibiting myofibre regeneration, or by generating antigenic peptides that are specific to muscle. Genetic variations within NOTCH4 could also influence susceptibility to sIBM through other mechanisms.
Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo
2004, BloodCitation Excerpt :The role of Notch4 in the hematopoietic system has not been studied. However, Notch4 has GATA recognition sites in its promoter region, transcription factors that play a role in lineage commitment in hematopoiesis,25,26 suggesting that Notch4 could play a role in hematopoiesis.5 Notch4 expression in hematopoiesis has so far been reported only in maturing macrophages with the use of single-cell polymerase chain reaction (PCR).27
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Sequence data described in this paper have been deposited with the EMBL/GenBank Data Libraries under Accession No. U89335 for the genomic sequence and Accession No. U95299 for the cDNA sequence of human NOTCH4.
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M. D. AdamsC. FieldsJ. C. Venter
- 1
L. Li and G. M. Huang made equal contributions to this work.
- 2
Present address: Pangea Systems Inc., 1999 Harrison Street, Suite 1100, Oakland, CA 94612.
- 3
To whom correspondence should be addressed at Department of Molecular Biotechnology, University of Washington, Box 357730, Seattle, WA 98195. Telephone: (206) 616-5104. Fax: (206) 685-7301.