Clinical Immunology and Immunopathology
Regular ArticleExpression of the Activation Antigen CD27 in Rheumatoid Arthritis
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Cited by (60)
Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography
2017, Molecular ImmunologySynovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology
2016, Kelley and Firestein's Textbook of Rheumatology: Volumes 1-2, Tenth EditionEnhanced costimulation by CD70+ B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice
2013, Journal of NeuroimmunologyCitation Excerpt :Their role in T cell activation appears not only to be determined by their BCR-related ability to capture and process autoantigens with high efficacy but also by their expression of costimulatory molecules. The transgenic overexpression model used in the present study may mimic to a certain extend the unchecked CD70 expression in humans during chronic viral infections and autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus (Wolthers et al., 1996; Oelke et al., 2004; Lee et al., 2007), or the CD70-CD27 interactions evidenced in rheumatoid arthritis (Tak et al., 1996). Strikingly, diseases such as RA and MS might be triggered by viral infections, including EBV infection of B cells (Franssila and Hedman, 2006; Sawada et al., 2007; Toussirot and Roudier, 2007; Franciotta et al., 2008; Pender, 2009, 2011), and show a profound clinical response to B cell depletion by anti-CD20 (Dorner et al., 2010; Townsend et al., 2010).
Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology
2012, Kelley's Textbook of Rheumatology: Volume 1-2, Ninth EditionCD27 expression on lymphocyte and sCD27 levels in children with asthma
2010, Allergologia et ImmunopathologiaCitation Excerpt :Antigen specific T cell activation also induces the release of a soluble form of CD27 (sCD27), probably as a result of proteolytic cleavage of CD27 transmembrane molecule.13,14 High levels of sCD27 have been detected in biological fluids taken from patients with B cell malignancies; chronic viral infections, such as HIV; and autoimmune disorders involving T cell hyperactivity, such as rheumatoid arthritis and systemic lupus erythematosus.15–17,8 Patients with multiple sclerosis also have increased levels of sCD27 in the cerebrospinal fluid.18
Soluble CD30 and Cd27 levels in patients undergoing HLA antibody-incompatible renal transplantation
2010, Transplant Immunology
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