Clinical Immunology and Immunopathology
Regular ArticleExpression of the Activation Antigen CD27 in Rheumatoid Arthritis
References (0)
Cited by (60)
Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography
2017, Molecular ImmunologySynovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology
2016, Kelley and Firestein's Textbook of Rheumatology: Volumes 1-2, Tenth EditionEnhanced costimulation by CD70+ B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice
2013, Journal of NeuroimmunologyCitation Excerpt :Their role in T cell activation appears not only to be determined by their BCR-related ability to capture and process autoantigens with high efficacy but also by their expression of costimulatory molecules. The transgenic overexpression model used in the present study may mimic to a certain extend the unchecked CD70 expression in humans during chronic viral infections and autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus (Wolthers et al., 1996; Oelke et al., 2004; Lee et al., 2007), or the CD70-CD27 interactions evidenced in rheumatoid arthritis (Tak et al., 1996). Strikingly, diseases such as RA and MS might be triggered by viral infections, including EBV infection of B cells (Franssila and Hedman, 2006; Sawada et al., 2007; Toussirot and Roudier, 2007; Franciotta et al., 2008; Pender, 2009, 2011), and show a profound clinical response to B cell depletion by anti-CD20 (Dorner et al., 2010; Townsend et al., 2010).
Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology
2012, Kelley's Textbook of Rheumatology: Volume 1-2, Ninth EditionCD27 expression on lymphocyte and sCD27 levels in children with asthma
2010, Allergologia et ImmunopathologiaCitation Excerpt :It has been reported that a large number of CD4+CD27+ T cells in the rheumatoid synovial perivasculer lymphocytic infiltrate a relative increase in the percentage of CD27–T cells in the diffuse lymphocytic infiltrate, and an increased percentage of CD4+ CD27− cells in synovial fluid. This might suggest a continuous influx of preactivated CD4+CD45RO+CD27+ cells from the peripheral blood into the synovial tissue of patients with rheumatoid arthritis and subsequent further activation and differentiation to CD4+CD45RO+CD27− cells in situ followed by migration to the synovial fluid.17 Similar results were also reported by Gattarno et al. in juvenile idiopathic arthritis.19
Soluble CD30 and Cd27 levels in patients undergoing HLA antibody-incompatible renal transplantation
2010, Transplant ImmunologyCitation Excerpt :CD27- cells do not differentiate into plasma cells in the presence of IL-10 and CD 70 transfectants [20]. High levels of soluble CD27 (sCD27) have been found in patients with autoimmune conditions involving T cell hyperactivity such as SLE [21] and rheumatoid arthritis [22] and in patients with B cell malignancies [23] and AIDS associated lymphoma [24]. Raised serum sCD27 has also been found to correlate with renal dysfunction [25].
- 1
To whom correspondence and requests for reprints should be addressed at Department of General Internal Medicine, Building 1, C1-R41, Leiden University Hospital, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Fax: 31 71 5248140.