Biochemical and Biophysical Research Communications
Regular ArticleSelective Deimination of Vimentin in Calcium Ionophore-Induced Apoptosis of Mouse Peritoneal Macrophages
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The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4
2023, Biochimica et Biophysica Acta - Proteins and ProteomicsCitrullination: A modification important in the pathogenesis of autoimmune diseases
2022, Clinical ImmunologyMicrobial pathways to subvert host immunity generate citrullinated neoantigens targeted in rheumatoid arthritis
2022, Current Opinion in Structural BiologyCitation Excerpt :A paradox in the study of PADs is that these enzymes require micromolar to millimolar amounts of calcium to achieve full activation in cells and in vitro [18,31]. Intracellular activation of PADs under these high calcium concentrations is, however, only observed during unique conditions, which also lead to cell death, such as keratinocyte differentiation, cytolysis induced by host or microbial pore-forming proteins, and artificially induced by calcium ionophores [13,31–36]. In keratinocytes, calcium-induced differentiation, citrullination, and cell death is a physiological process leading to skin keratinization and moisturizing [32].
Peptidylarginine deiminase-4: Medico-formulative strategy towards management of rheumatoid arthritis
2022, Biochemical PharmacologyBiochemical and biophysical characterization of PADI4 supports its involvement in cancer
2022, Archives of Biochemistry and BiophysicsCitation Excerpt :Although the full consequences of the modification of the positive charge of the guanidino group of arginine to the neutral ureido group of citrulline are unknown, it is thought that such PTM induces local protein unfolding, impairing the formation of functional tertiary structures [1,2]. PADIs have key roles in nerve growth, onset of inflammation states, embryonic development, tissue aging, epithelial terminal differentiation, trauma apoptosis and transcriptional regulation of gene expression and regulation [3–10]. Furthermore, several human diseases such as Alzheimer's disease, rheumatoid arthritis, multiple sclerosis, psoriasis and different types of cancers are associated with the presence of PADIs and their citrullinated targets [9,11–13].
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