Editorials:

Diagnosing axial spondyloarthropathy. The new Assessment in SpondyloArthritis international Society criteria: MRI entering centre stage

A N Bennett, H Marzo-Ortega, P Emery, D McGonagle on behalf of the Leeds Spondyloarthropathy Group

Ann Rheum Dis 2009; 68: 765-767. doi:10.1136/ard.2009.111435

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New tumour necrosis factor inhibitors for rheumatoid arthritis: are there benefits from extending choice?

David L Scott and Andrew Cope

Ann Rheum Dis 2009; 68: 767-769. doi:10.1136/ard.2008.105940

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Letters:

Tendency towards erosive regression on magnetic resonance imaging at 12 months in rheumatoid arthritis patients treated with rituximab

U Møller Døhn, M Østergaard, P Bird, A Boonen, J S Johansen, J M Møller, and M S Hansen

Ann Rheum Dis 2009; 68: 1072-1073. doi:10.1136/ard.2008.098962

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Diagnostic value of procalcitonin for differentiation between bacterial infection and non-infectious inflammation in febrile patients with active adult-onset Still’s disease

D-Y Chen, Y-M Chen, W-L Ho, H-H Chen, G-H Shen, and J-L Lan

Ann Rheum Dis 2009; 68: 1074-1075. doi:10.1136/ard.2008.098335

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Rituximab fixed retreatment versus on-demand retreatment in refractory rheumatoid arthritis: comparison of two B cell depleting treatment strategies

Y K O Teng, J Tekstra, F C Breedveld, F Lafeber, J W J Bijlsma, and Jacob M van Laar

Ann Rheum Dis 2009; 68: 1075-1077. doi:10.1136/ard.2008.100438

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Refractory severe connective tissue disease thrombocytopenia: is rituximab treatment effective and safe?

W J Zheng, X Zhang, Q Wang, D Xu, X F Zeng, and F C Zhang

Ann Rheum Dis 2009; 68: 1077-1078. doi:10.1136/ard.2008.098293

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Erosive osteoarthritis of the hand: clinical experience with anakinra

L Bacconnier, C Jorgensen, and S Fabre

Ann Rheum Dis 2009; 68: 1078-1079. doi:10.1136/ard.2008.094284

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Miscellaneous:

Corrections

Ann Rheum Dis 2009; 68: 1080. doi:10.1136/ard.2007.085050.corr1

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Corrections

Ann Rheum Dis 2009; 68: 1080. doi:10.1136/ard.2008.094508.corr1

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Corrections

Ann Rheum Dis 2009; 68: 1080. doi:10.1136/ard.2008.099408.corr1

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Basic and translational research:

Hsp90β and p130^cas: novel regulatory factors of MMP-13 expression in human osteoarthritic chondrocytes

Z Fan, G Tardif, D Hum, N Duval, J-P Pelletier, and J Martel-Pelletier

Ann Rheum Dis 2009; 68: 976-982.
Published Online First: 1 July 2008. doi:10.1136/ard.2008.092288

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Thymic function in juvenile idiopathic arthritis

A R Lorenzi, T A Morgan, A Anderson, J Catterall, A M Patterson, H E Foster, and J D Isaacs

Ann Rheum Dis 2009; 68: 983-990.
Published Online First: 15 July 2008. doi:10.1136/ard.2008.088112

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Severe alterations in expression and localisation of 6β4 integrin in salivary gland acini from patients with Sjögren syndrome

J Velozo, S Aguilera, C Alliende, P Ewert, C Molina, P Pérez, L Leyton, A Quest, M Brito, S González, C Leyton, M Hermoso, R Romo, and M-J González

Ann Rheum Dis 2009; 68: 991-996.
Published Online First: 14 July 2008. doi:10.1136/ard.2008.089607

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Serum levels of tumour necrosis factor family members a proliferation-inducing ligand (APRIL) and B lymphocyte stimulator (BLyS) are inversely correlated in systemic lupus erythematosus

J Morel, C Roubille, L Planelles, C Rocha, L Fernandez, C Lukas, M Hahne, and B Combe

Ann Rheum Dis 2009; 68: 997-1002.
Published Online First: 2 August 2008. doi:10.1136/ard.2008.090928

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Evidence for a distinctive pattern of bone formation in enthesophytes

M Benjamin, H Toumi, D Suzuki, K Hayashi, and D McGonagle

Ann Rheum Dis 2009; 68: 1003-1010.
Published Online First: 14 July 2008. doi:10.1136/ard.2008.091074

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Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation

Y K O Teng, E W N Levarht, Rene E M Toes, Tom W J Huizinga, and Jacob M van Laar

Ann Rheum Dis 2009; 68: 1011-1016.
Published Online First: 22 July 2008. doi:10.1136/ard.2008.092791

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Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections

R Dieguez-Gonzalez, M Calaza, D Shi, I Meulenbelt, J Loughlin, A Tsezou, J Dai, K N Malizos, E P Slagboom, M Kloppenburg, K Chapman, Q Jiang, D Kremer, J J Gomez-Reino, N Nakajima, S Ikegawa, and A Gonzalez

Ann Rheum Dis 2009; 68: 1017-1021.
Published Online First: 14 July 2008. doi:10.1136/ard.2008.093641

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Exposure to nuclear antigens contributes to the induction of humoral autoimmunity during tumour necrosis factor alpha blockade

T Cantaert, L De Rycke, C P Mavragani, C A Wijbrandts, T B Niewold, T Niers, B Vandooren, E M Veys, D Richel, P P Tak, M K Crow, and D Baeten

Ann Rheum Dis 2009; 68: 1022-1029.
Published Online First: 14 July 2008. doi:10.1136/ard.2008.093724

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Complement activation in patients with primary antiphospholipid syndrome

K Oku, T Atsumi, M Bohgaki, O Amengual, H Kataoka, T Horita, S Yasuda, and T Koike

Ann Rheum Dis 2009; 68: 1030-1035.
Published Online First: 14 July 2008. doi:10.1136/ard.2008.090670

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Regulation of CXCL16 expression and secretion by myeloid cells is not altered in rheumatoid arthritis

A W T van Lieshout, R van der Voort, L W J Toonen, S F G van Helden, C G Figdor, P L C M van Riel, T R D J Radstake, and G J Adema

Ann Rheum Dis 2009; 68: 1036-1043.
Published Online First: 15 July 2008. doi:10.1136/ard.2007.086611

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Melanoma inhibitory activity, a biomarker related to chondrocyte anabolism, is reversibly suppressed by proinflammatory cytokines in rheumatoid arthritis

B Vandooren, T Cantaert, M-J van Lierop, E Bos, L De Rycke, E M Veys, F De Keyser, B Bresnihan, F P Luyten, P C Verdonk, P P Tak, A H Boots, and D Baeten

Ann Rheum Dis 2009; 68: 1044-1050.
Published Online First: 16 July 2008. doi:10.1136/ard.2007.085837

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Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes

T Yatabe, S Mochizuki, M Takizawa, M Chijiiwa, A Okada, T Kimura, Y Fujita, H Matsumoto, Y Toyama, and Y Okada

Ann Rheum Dis 2009; 68: 1051-1058.
Published Online First: 28 July 2008. doi:10.1136/ard.2007.086884

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Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis

M B Nickdel, P Conigliaro, G Valesini, S Hutchison, R Benson, R V Bundick, A J Leishman, I B McInnes, J M Brewer, and P Garside

Ann Rheum Dis 2009; 68: 1059-1066.
Published Online First: 17 July 2008. doi:10.1136/ard.2008.089300

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Severe impaired respiratory ciliary function in Wegener granulomatosis

S Ullrich, H Gustke, P Lamprecht, W L Gross, U Schumacher, P Ambrosch, and M Laudien

Ann Rheum Dis 2009; 68: 1067-1071.
Published Online First: 21 November 2008. doi:10.1136/ard.2008.096974

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Clinical and epidemiological research:

The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal

M Rudwaleit, R Landewé, D van der Heijde, J Listing, J Brandt, J Braun, R Burgos-Vargas, E Collantes-Estevez, J Davis, B Dijkmans, M Dougados, P Emery, I E van der Horst-Bruinsma, R Inman, M A Khan, M Leirisalo-Repo, S van der Linden, W P Maksymowych, H Mielants, I Olivieri, R Sturrock, K de Vlam, and J Sieper

Ann Rheum Dis 2009; 68: 770-776.
Published Online First: 17 March 2009. doi:10.1136/ard.2009.108217

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The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection

M Rudwaleit, D van der Heijde, R Landewé, J Listing, N Akkoc, J Brandt, J Braun, C T Chou, E Collantes-Estevez, M Dougados, F Huang, J Gu, M A Khan, Y Kirazli, W P Maksymowych, H Mielants, I J Sørensen, S Ozgocmen, E Roussou, R Valle-Oñate, U Weber, J Wei, and J Sieper

Ann Rheum Dis 2009; 68: 777-783.
Published Online First: 17 March 2009. doi:10.1136/ard.2009.108233

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New criteria for inflammatory back pain in patients with chronic back pain: a real patient exercise by experts from the Assessment of SpondyloArthritis international Society (ASAS)

J Sieper, D van der Heijde, R Landewé, J Brandt, R Burgos-Vagas, E Collantes-Estevez, B Dijkmans, M Dougados, M A Khan, M Leirisalo-Repo, S van der Linden, W P Maksymowych, H Mielants, I Olivieri, and M Rudwaleit

Ann Rheum Dis 2009; 68: 784-788.
Published Online First: 15 January 2009. doi:10.1136/ard.2008.101501

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Golimumab, a human antibody to tumour necrosis factor given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study

E C Keystone, M C Genovese, L Klareskog, E C Hsia, S T Hall, P C Miranda, J Pazdur, S-C Bae, W Palmer, J Zrubek, M Wiekowski, S Visvanathan, Z Wu, and M U Rahman

Ann Rheum Dis 2009; 68: 789-796.
Published Online First: 9 December 2008. doi:10.1136/ard.2008.099010

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Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study. A randomised controlled trial

J Smolen, R B Landewé, P Mease, J Brzezicki, D Mason, K Luijtens, R F van Vollenhoven, A Kavanaugh, M Schiff, G R Burmester, V Strand, J Vencovsky, and D van der Heijde

Ann Rheum Dis 2009; 68: 797-804.
Published Online First: 17 November 2008. doi:10.1136/ard.2008.101659

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Efficacy and safety of certolizumab pegol monotherapy every 4 weeks in patients with rheumatoid arthritis failing previous disease-modifying antirheumatic therapy: the FAST4WARD study

R Fleischmann, J Vencovsky, R F van Vollenhoven, D Borenstein, J Box, G Coteur, N Goel, H-P Brezinschek, A Innes, and V Strand

Ann Rheum Dis 2009; 68: 805-811.
Published Online First: 17 November 2008. doi:10.1136/ard.2008.099291

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Impaired memory and learning abilities in patients with systemic lupus erythematosus as measured by the Rey Auditory Verbal Learning Test

D Paran, I Litinsky, I Shapira-Lichter, S Navon, T Hendler, D Caspi, and E Vakil

Ann Rheum Dis 2009; 68: 812-816.
Published Online First: 1 July 2008. doi:10.1136/ard.2008.091538

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Vitamin D and chronic widespread pain in a white middle-aged British population: evidence from a cross-sectional population survey

K Atherton, D J Berry, T Parsons, G J Macfarlane, C Power, and E Hyppönen

Ann Rheum Dis 2009; 68: 817-822.
Published Online First: 12 August 2008. doi:10.1136/ard.2008.090456

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Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: the impacts of remission and tumour necrosis factor blockade

J S Smolen, C Han, D M F M van der Heijde, P Emery, J M Bathon, E Keystone, R N Maini, J R Kalden, D Aletaha, D Baker, J Han, M Bala, E W St Clair, and for the Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset (ASPIRE) Study Group

Ann Rheum Dis 2009; 68: 823-827.
Published Online First: 1 July 2008. doi:10.1136/ard.2008.090019

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Disease progression in mothers of children enrolled in the Research Registry for Neonatal Lupus

T L Rivera, P M Izmirly, B K Birnbaum, P Byrne, J B Brauth, M Katholi, M Y Kim, J Fischer, R M Clancy, and J P Buyon

Ann Rheum Dis 2009; 68: 828-835.
Published Online First: 14 July 2008. doi:10.1136/ard.2008.088054

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Increased serum levels of B cell activating factor (BAFF) in subsets of patients with idiopathic inflammatory myopathies

O Krystufková, T Vallerskog, S Barbasso Helmers, H Mann, I Putová, J Belácek, V Malmström, C Trollmo, J Vencovsky, and I E Lundberg

Ann Rheum Dis 2009; 68: 836-843.
Published Online First: 15 July 2008. doi:10.1136/ard.2008.091405

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Evaluating guidelines on continuation of anti-tumour necrosis factor treatment after 3 months: clinical effectiveness and costs of observed care and different alternative strategies

W Kievit, J Fransen, E M Adang, H H Kuper, T L Jansen, C M A De Gendt, D J R A M De Rooij, H L M Brus, M A F J van de Laar, and P C L M Van Riel

Ann Rheum Dis 2009; 68: 844-849.
Published Online First: 14 July 2008. doi:10.1136/ard.2008.094359

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Bone marrow lesions predict increase in knee cartilage defects and loss of cartilage volume in middle-aged women without knee pain over 2 years

A E Wluka, F Hanna, M Davies-Tuck, Y Wang, R J Bell, S R Davis, J Adams, and F M Cicuttini

Ann Rheum Dis 2009; 68: 850-855.
Published Online First: 14 July 2008. doi:10.1136/ard.2008.092221

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Geographical variation of disease manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials and Research (EUSTAR) group database

U A Walker, A Tyndall, L Czirják, C P Denton, D Farge-Bancel, O Kowal-Bielecka, U Müller-Ladner, M Matucci-Cerinic, and and the EUSTAR co-authors

Ann Rheum Dis 2009; 68: 856-862.
Published Online First: 14 July 2008. doi:10.1136/ard.2008.091348

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Physical function in ankylosing spondylitis is independently determined by both disease activity and radiographic damage of the spine

R Landewé, M Dougados, H Mielants, H van der Tempel, and D van der Heijde

Ann Rheum Dis 2009; 68: 863-867.
Published Online First: 15 July 2008. doi:10.1136/ard.2008.091793

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Anti-inflammatory therapy with tumour necrosis factor alpha inhibitors improves high-density lipoprotein cholesterol antioxidative capacity in rheumatoid arthritis patients

C Popa, L J H van Tits, P Barrera, H L M Lemmers, F H J van den Hoogen, P L C M van Riel, T R D J Radstake, M G Netea, M Roest, and A F H Stalenhoef

Ann Rheum Dis 2009; 68: 868-872.
Published Online First: 17 July 2008. doi:10.1136/ard.2008.092171

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Wegener’s granulomatosis patients show an adequate antibody response to influenza vaccination

A Holvast, C A Stegeman, C A Benne, A Huckriede, J C Wilschut, A M Palache, C G M Kallenberg, and M Bijl

Ann Rheum Dis 2009; 68: 873-878.
Published Online First: 14 July 2008. doi:10.1136/ard.2008.092924

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Responsiveness of the International Classification of Functioning, Disability and Health (ICF) Core Set for rheumatoid arthritis

T Uhlig, R Moe, S Reinsberg, T K Kvien, A Cieza, and G Stucki

Ann Rheum Dis 2009; 68: 879-884.
Published Online First: 14 July 2008. doi:10.1136/ard.2008.088708

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Evaluation of work-related psychosocial factors and regional musculoskeletal pain: results from a EULAR Task Force

G J Macfarlane, N Pallewatte, P Paudyal, F M Blyth, D Coggon, G Crombez, S Linton, P Leino-Arjas, A J Silman, R J Smeets, and D van der Windt

Ann Rheum Dis 2009; 68: 885-891.
Published Online First: 22 August 2008. doi:10.1136/ard.2008.090829

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A randomised controlled trial on the efficacy and tolerability with dose escalation of allopurinol 300–600 mg/day versus benzbromarone 100–200 mg/day in patients with gout

M K Reinders, C Haagsma, T L Th A Jansen, E N van Roon, J Delsing, M A F J van de Laar, and J R B J Brouwers

Ann Rheum Dis 2009; 68: 892-897.
Published Online First: 16 July 2008. doi:10.1136/ard.2008.091462

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Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis

B Hoppe, T Häupl, K Egerer, R Gruber, H Kiesewetter, A Salama, G R Burmester, and T Dörner

Ann Rheum Dis 2009; 68: 898-903.
Published Online First: 16 July 2008. doi:10.1136/ard.2008.091983

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The natural history of bone marrow lesions in community-based adults with no clinical knee osteoarthritis

M L Davies-Tuck, A E Wluka, Y Wang, D R English, G G Giles, and F Cicuttini

Ann Rheum Dis 2009; 68: 904-908.
Published Online First: 3 August 2008. doi:10.1136/ard.2008.092973

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Obesity and adiposity are associated with the rate of patella cartilage volume loss over 2 years in adults without knee osteoarthritis

A J Teichtahl, A E Wluka, Y Wang, F Hanna, D R English, G G Giles, and F M Cicuttini

Ann Rheum Dis 2009; 68: 909-913.
Published Online First: 16 July 2008. doi:10.1136/ard.2008.093310

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Drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients with recent-onset rheumatoid arthritis

S M van der Kooij, Y P M Goekoop-Ruiterman, J K de Vries-Bouwstra, M Güler-Yüksel, A H Zwinderman, P J S M Kerstens, P A H M van der Lubbe, W M de Beus, B A M Grillet, H K Ronday, T W J Huizinga, F C Breedveld, B A C Dijkmans, and C F Allaart

Ann Rheum Dis 2009; 68: 914-921.
Published Online First: 28 July 2008. doi:10.1136/ard.2008.092254

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Adalimumab effectiveness for the treatment of ankylosing spondylitis is maintained for up to 2 years: long-term results from the ATLAS trial

D van der Heijde, M H Schiff, J Sieper, A J Kivitz, R L Wong, H Kupper, B A C Dijkmans, P J Mease, J C Davis, Jr, and for the ATLAS Study Group

Ann Rheum Dis 2009; 68: 922-929.
Published Online First: 13 August 2008. doi:10.1136/ard.2007.087270

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Impact of adalimumab on work participation in rheumatoid arthritis: comparison of an open-label extension study and a registry-based control group

M T Halpern, M A Cifaldi, and T K Kvien

Ann Rheum Dis 2009; 68: 930-937.
Published Online First: 1 October 2008. doi:10.1136/ard.2008.092734

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Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI

J-P Raynauld, J Martel-Pelletier, P Bias, S Laufer, B Haraoui, D Choquette, A D Beaulieu, F Abram, M Dorais, É Vignon, J-P Pelletier, and and the Canadian Licofelone Study Group

Ann Rheum Dis 2009; 68: 938-947.
Published Online First: 23 July 2008. doi:10.1136/ard.2008.088732

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Development and validation of the Spondyloarthritis Research Consortium of Canada (SPARCC) Enthesitis Index

W P Maksymowych, C Mallon, S Morrow, K Shojania, W P Olszynski, R L Wong, J Sampalis, and B Conner-Spady

Ann Rheum Dis 2009; 68: 948-953.
Published Online First: 4 June 2008. doi:10.1136/ard.2007.084244

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Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate

G Wells, J-C Becker, J Teng, M Dougados, M Schiff, J Smolen, D Aletaha, and P L C M van Riel

Ann Rheum Dis 2009; 68: 954-960.
Published Online First: 19 May 2008. doi:10.1136/ard.2007.084459

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Systemic sclerosis and its pulmonary complications in The Netherlands: an epidemiological study

M C Vonk, B Broers, Y F Heijdra, E Ton, R Snijder, A P J van Dijk, J M van Laar, H Bootsma, P Th W van Hal, F H J van den Hoogen, and P L A van Daele

Ann Rheum Dis 2009; 68: 961-965.
Published Online First: 29 May 2008. doi:10.1136/ard.2008.091710

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Thoracoabdominal motion in ankylosing spondylitis: association with standardised clinical measures and response to therapy

G E Tzelepis, G Kalliakosta, A G Tzioufas, P P Sfikakis, C Mandros, K A Boki, C Roussos, and H M Moutsopoulos

Ann Rheum Dis 2009; 68: 966-971.
Published Online First: 16 July 2008. doi:10.1136/ard.2008.092650

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Test–retest reliability of disease activity core set measures and indices in rheumatoid arthritis

T Uhlig, T K Kvien, and T Pincus

Ann Rheum Dis 2009; 68: 972-975.
Published Online First: 28 October 2008. doi:10.1136/ard.2008.097345

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