Editorials:

Optimal use of methotrexate: the advantages of tight control

J W J Bijlsma and M E Weinblatt

Ann Rheum Dis 2007; 66: 1409-1410. doi:10.1136/ard.2007.076463

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Reviews:

Cellular targets of interleukin-18 in rheumatoid arthritis

Sheng-Ming Dai, Zheng-Zheng Shan, Huji Xu, and Kusuki Nishioka

Ann Rheum Dis 2007; 66: 1411-1418.
Published Online First: 14 May 2007. doi:10.1136/ard.2006.067793

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Extended reports:

A novel gene variation of TNF associated with ankylosing spondylitis: a reconfirmed study

Xiaoquan Zhu, Yawen Wang, Liang Sun, Yuguo Song, Fei Sun, Lei Tang, Zhenghao Huo, Jianxin Li, and Ze Yang

Ann Rheum Dis 2007; 66: 1419-1422.
Published Online First: 1 May 2007. doi:10.1136/ard.2006.068528

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Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis

Sunita Suri, Sarah E Gill, Sally Massena de Camin, Daniel F McWilliams, Deborah Wilson, and David A Walsh

Ann Rheum Dis 2007; 66: 1423-1428.
Published Online First: 19 April 2007. doi:10.1136/ard.2006.063354

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Gelatinase expression and proteolytic activity in giant-cell arteritis

Marta Segarra, Ana García-Martínez, Montse Sánchez, José Hernández-Rodríguez, Ester Lozano, Josep M Grau, and Maria C Cid

Ann Rheum Dis 2007; 66: 1429-1435.
Published Online First: 14 May 2007. doi:10.1136/ard.2006.068148

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The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis

B Z Alizadeh, O T Njajou, J M W Hazes, A Hofman, P E Slagboom, H A P Pols, and C M van Duijn

Ann Rheum Dis 2007; 66: 1436-1442.
Published Online First: 6 February 2007. doi:10.1136/ard.2006.063099

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Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)

S M M Verstappen, J W G Jacobs, M J van der Veen, A H M Heurkens, Y Schenk, E J ter Borg, A A M Blaauw, J W J Bijlsma, and on the behalf of the Utrecht Rheumatoid Arthritis Cohort study group

Ann Rheum Dis 2007; 66: 1443-1449.
Published Online First: 22 May 2007. doi:10.1136/ard.2007.071092

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Autoantibodies binding to citrullinated telopeptide of type II collagen and to cyclic citrullinated peptides predict synergistically the development of seropositive rheumatoid arthritis

Marja-Kaisa Koivula, Markku Heliövaara, Jarmo Ramberg, Paul Knekt, Harri Rissanen, Timo Palosuo, and Juha Risteli

Ann Rheum Dis 2007; 66: 1450-1455.
Published Online First: 1 May 2007. doi:10.1136/ard.2006.062919

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Predicting poor functional outcome in community-dwelling older adults with knee pain: prognostic value of generic indicators

Christian D Mallen, George Peat, Elaine Thomas, Rosie Lacey, and Peter Croft

Ann Rheum Dis 2007; 66: 1456-1461.
Published Online First: 24 April 2007. doi:10.1136/ard.2006.067975

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Low-dose glucocorticoid therapy decreases risk for treatment-limiting infusion reaction to infliximab in patients with rheumatoid arthritis

Jenny Augustsson, Staffan Eksborg, Sofia Ernestam, Eleanor Gullström, and Ronald van Vollenhoven

Ann Rheum Dis 2007; 66: 1462-1466.
Published Online First: 14 May 2007. doi:10.1136/ard.2007.070771

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Selective endothelin_A receptor antagonism with sitaxsentan for pulmonary arterial hypertension associated with connective tissue disease

Reda E Girgis, Adaani E Frost, Nicholas S Hill, Evelyn M Horn, David Langleben, Vallerie V McLaughlin, Ronald J Oudiz, Ivan M Robbins, James R Seibold, Shelley Shapiro, Victor F Tapson, and Robyn J Barst

Ann Rheum Dis 2007; 66: 1467-1472.
Published Online First: 1 May 2007. doi:10.1136/ard.2007.069609

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The efficacy of anti-TNF in rheumatoid arthritis, a comparison between randomised controlled trials and clinical practice

W Kievit, J Fransen, A J M Oerlemans, H H Kuper, M A F J van der Laar, D J R A M de Rooij, C M A De Gendt, K H Ronday, T L Jansen, P C M van Oijen, H L M Brus, E M Adang, and P L C M van Riel

Ann Rheum Dis 2007; 66: 1473-1478.
Published Online First: 10 April 2007. doi:10.1136/ard.2007.072447

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Performance of referral recommendations in patients with chronic back pain and suspected axial spondyloarthritis

Henning Christian Brandt, Inge Spiller, In-Ho Song, Janis L Vahldiek, Martin Rudwaleit, and Joachim Sieper

Ann Rheum Dis 2007; 66: 1479-1484.
Published Online First: 24 April 2007. doi:10.1136/ard.2006.068734

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Changes in priorities for improvement in patients with rheumatoid arthritis during 1 year of anti-tumour necrosis factor treatment

Peter M ten Klooster, Martine M Veehof, Erik Taal, Piet L C M van Riel, and Mart A F J van de Laar

Ann Rheum Dis 2007; 66: 1485-1490.
Published Online First: 1 May 2007. doi:10.1136/ard.2007.069765

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QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries

Tuulikki Sokka, Hannu Kautiainen, Sergio Toloza, Heidi Mäkinen, Suzan M M Verstappen, Merete Lund Hetland, Antonio Naranjo, Eva Baecklund, Gertraud Herborn, Rolf Rau, Massimiliano Cazzato, Laure Gossec, Vlado Skakic, Feride Gogus, Stanislaw Sierakowski, Barry Bresnihan, Peter Taylor, Catherine McClinton, Theodore Pincus, and for the QUEST-RA Group

Ann Rheum Dis 2007; 66: 1491-1496.
Published Online First: 5 April 2007. doi:10.1136/ard.2006.069252

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Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis

N A Shadick, J E Heller, M E Weinblatt, N E Maher, J Cui, G Ginsburg, J Coblyn, R Anderson, D H Solomon, R Roubenoff, and A Parker

Ann Rheum Dis 2007; 66: 1497-1502.
Published Online First: 9 May 2007. doi:10.1136/ard.2006.067603

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Modulation of lipoprotein plasma concentrations during long-term anti-TNF therapy in patients with active rheumatoid arthritis

Calin Popa, Frank H J van den Hoogen, Timothy R D J Radstake, Mihai G Netea, Agnes E Eijsbouts, Martin den Heijer, Jos W M van der Meer, Piet L C M van Riel, Anton F H Stalenhoef, and Pilar Barrera

Ann Rheum Dis 2007; 66: 1503-1507.
Published Online First: 1 May 2007. doi:10.1136/ard.2006.066191

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Bone mineral density in patients with recently diagnosed, active rheumatoid arthritis

M Güler-Yüksel, J Bijsterbosch, Y P M Goekoop-Ruiterman, F C Breedveld, C F Allaart, J K de Vries-Bouwstra, B A C Dijkmans, W F Lems, H K Ronday, A J Peeters, and J M de Jonge-Bok

Ann Rheum Dis 2007; 66: 1508-1512.
Published Online First: 24 April 2007. doi:10.1136/ard.2007.070839

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Hand bone densitometry: a more sensitive standard for the assessment of early bone damage in rheumatoid arthritis

Glenn Haugeberg, Michael J Green, Philip G Conaghan, Mark Quinn, Richard Wakefield, Susanna M Proudman, Sheena Stewart, Elizabeth Hensor, and Paul Emery

Ann Rheum Dis 2007; 66: 1513-1517.
Published Online First: 9 May 2007. doi:10.1136/ard.2006.067652

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Long-term outcome of juvenile idiopathic arthritis following a placebo-controlled trial: sustained benefits of early sulfasalazine treatment

Marion A J van Rossum, Renée M van Soesbergen, Maarten Boers, Aeilko H Zwinderman, Theo J W Fiselier, Marcel J A M Franssen, Rebecca ten Cate, Lisette W A van Suijlekom-Smit, Nico M Wulffraat, Wietse Kuis, Wilma H J van Luijk, Johanna C M Oostveen, Ben A C Dijkmans, and on behalf of the Dutch Juvenile Idiopathic Arthritis Study group

Ann Rheum Dis 2007; 66: 1518-1524.
Published Online First: 9 May 2007. doi:10.1136/ard.2006.064717

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Macrophage migration inhibitory factor polymorphisms do not predict therapeutic response to glucocorticoids or to tumour necrosis factor -neutralising treatments in rheumatoid arthritis

Timothy R D J Radstake, Jaap Fransen, Erik J M Toonen, Marieke J H Coenen, Agnes E Eijsbouts, Rachelle Donn, Frank H J van den Hoogen, and Piet L C M van Riel

Ann Rheum Dis 2007; 66: 1525-1530.
Published Online First: 24 April 2007. doi:10.1136/ard.2006.064394

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Concise reports:

The association of the PTPN22 620W polymorphism with Behçet’s disease

Vijay Baranathan, Miles R Stanford, Robert W Vaughan, Elli Kondeatis, Elizabeth Graham, Farida Fortune, Wafa Madanat, Charlie Kanawati, Marwen Ghabra, Philip I Murray, and Graham R Wallace

Ann Rheum Dis 2007; 66: 1531-1533.
Published Online First: 27 July 2007. doi:10.1136/ard.2007.073866

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Limited correlation between the Health Assessment Questionnaire (HAQ) and EuroQol in rheumatoid arthritis: questionable validity of deriving quality adjusted life years from HAQ

D L Scott, B Khoshaba, E H Choy, and G H Kingsley

Ann Rheum Dis 2007; 66: 1534-1537.
Published Online First: 27 July 2007. doi:10.1136/ard.2007.073726

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Does extremity-MRI improve erosion detection in severely damaged joints? A study of long-standing rheumatoid arthritis using three imaging modalities

J E Freeston, P G Conaghan, S Dass, E Vital, E M A Hensor, S Stewart, and P Emery

Ann Rheum Dis 2007; 66: 1538-1540.
Published Online First: 31 July 2007. doi:10.1136/ard.2007.074708

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Letters:

Coexistent MEFV and CIAS1 mutations manifesting as familial Mediterranean fever plus deafness

Davinder Singh-Grewal, Jeffrey Chaitow, Ivona Aksentijevich, and John Christodoulou

Ann Rheum Dis 2007; 66: 1541. doi:10.1136/ard.2007.075655

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Metabolic syndrome in systemic lupus erythematosus: lower prevalence in Brazil than in the USA

George D Azevedo, Rafael G N Gadelha, and Maria José Vilar

Ann Rheum Dis 2007; 66: 1542. doi:10.1136/ard.2007.074583

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Incidence and predictors of severe extra-articular disease manifestations in an early rheumatoid arthritis inception cohort

C Turesson, K Eberhardt, L T H Jacobsson, and E Lindqvist

Ann Rheum Dis 2007; 66: 1543-1544. doi:10.1136/ard.2007.076521

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The use of the tumour necrosis factor antagonist infliximab in heart transplant recipients: two case reports

S Metyas, D La, and D G Arkfeld

Ann Rheum Dis 2007; 66: 1544-1545. doi:10.1136/ard.2007.070383

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Effective treatment of a colchicine-resistant familial Mediterranean fever patient with anakinra

Loes M Kuijk, Anita M A P Govers, Willem J D Hofhuis, and Joost Frenkel

Ann Rheum Dis 2007; 66: 1545-1546. doi:10.1136/ard.2007.071498

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Relationship between blood hydroxychloroquine and desethylchloroquine concentrations and cigarette smoking in treated patients with connective tissue diseases

Gaëlle Leroux, Nathalie Costedoat-Chalumeau, Jean-Sébastien Hulot, Zahir Amoura, Camille Francès, Guy Aymard, Philippe Lechat, and Jean-Charles Piette

Ann Rheum Dis 2007; 66: 1547-1548. doi:10.1136/ard.2007.072587

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Corrections:

Corrections

Ann Rheum Dis 2007; 66: 1548. doi:10.1136/ard.2006.062760.corr1

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Corrections

Ann Rheum Dis 2007; 66: 1548. doi:10.1136/ard.2006.063230.corr1

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