Editorials:

Yet more evidence that osteoarthritis is not a cartilage disease

K D Brandt, E L Radin, P A Dieppe, and L van de Putte

Ann Rheum Dis 2006; 65: 1261-1264. doi:10.1136/ard.2006.058347

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Osteoarthritis linkage scan: more loci for the geneticists to investigate

J Loughlin

Ann Rheum Dis 2006; 65: 1265-1266. doi:10.1136/ard.2006.053967

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Extended reports:

Combined high-resolution magnetic resonance imaging and histological examination to explore the role of ligaments and tendons in the phenotypic expression of early hand osteoarthritis

A L Tan, H Toumi, M Benjamin, A J Grainger, S F Tanner, P Emery, and D McGonagle

Ann Rheum Dis 2006; 65: 1267-1272.
Published Online First: 20 April 2006. doi:10.1136/ard.2005.050112

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Genetic characterisation of spontaneous ankylosing arthropathy with unique inheritance from Fas-deficient strains of mice

S Mori, M-C Zhang, N Tanda, F Date, M Nose, H Furukawa, and M Ono

Ann Rheum Dis 2006; 65: 1273-1278.
Published Online First: 28 March 2006. doi:10.1136/ard.2005.050526

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Expression of the peptide C4b-binding protein ß in the arthritic joint

O Sánchez-Pernaute, J Esparza-Gordillo, R Largo, E Calvo, M A Alvarez-Soria, M E Marcos, G Herrero-Beaumont, and S R de Córdoba

Ann Rheum Dis 2006; 65: 1279-1285.
Published Online First: 5 May 2006. doi:10.1136/ard.2006.052118

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Pretreatment macrophage infiltration of the synovium predicts the clinical effect of both radiation synovectomy and intra-articular glucocorticoids

Z N Jahangier, J W G Jacobs, M C Kraan, M J G Wenting, T J Smeets, J W J Bijlsma, F P J G Lafeber, and P P Tak

Ann Rheum Dis 2006; 65: 1286-1292.
Published Online First: 20 April 2006. doi:10.1136/ard.2005.042333

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Altered gut transcriptome in spondyloarthropathy

D Laukens, H Peeters, B V Cruyssen, T Boonefaes, D Elewaut, F De Keyser, H Mielants, C Cuvelier, E M Veys, K Knecht, P Van Hummelen, E Remaut, L Steidler, M De Vos, and P Rottiers

Ann Rheum Dis 2006; 65: 1293-1300.
Published Online First: 13 February 2006. doi:10.1136/ard.2005.047738

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EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the standing committee for international clinical studies including therapeutics (ESCISIT)

W Zhang, M Doherty, E Pascual, T Bardin, V Barskova, P Conaghan, J Gerster, J Jacobs, B Leeb, F Lioté, G McCarthy, P Netter, G Nuki, F Perez-Ruiz, A Pignone, J Pimentão, L Punzi, E Roddy, T Uhlig, and I Zimmermann-Gòrska

Ann Rheum Dis 2006; 65: 1301-1311.
Published Online First: 17 May 2006. doi:10.1136/ard.2006.055251

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EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee For International Clinical Studies Including Therapeutics (ESCISIT)

W Zhang, M Doherty, T Bardin, E Pascual, V Barskova, P Conaghan, J Gerster, J Jacobs, B Leeb, F Lioté, G McCarthy, P Netter, G Nuki, F Perez-Ruiz, A Pignone, J Pimentão, L Punzi, E Roddy, T Uhlig, and I Zimmermann-Gòrska

Ann Rheum Dis 2006; 65: 1312-1324.
Published Online First: 17 May 2006. doi:10.1136/ard.2006.055269

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Minimally important difference in diffuse systemic sclerosis: results from the D-penicillamine study

D Khanna, D E Furst, R D Hays, G S Park, W K Wong, J R Seibold, M D Mayes, B White, F F Wigley, M Weisman, W Barr, L Moreland, T A Medsger, Jr, V D Steen, R W Martin, D Collier, A Weinstein, E V Lally, J Varga, S R Weiner, B Andrews, M Abeles, and P J Clements

Ann Rheum Dis 2006; 65: 1325-1329.
Published Online First: 15 March 2006. doi:10.1136/ard.2005.050187

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The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus

G Oroszi, L Lapteva, E Davis, C H Yarboro, T Weickert, T Roebuck-Spencer, J Bleiberg, D Rosenstein, M Pao, P E Lipsky, D Goldman, R H Lipsky, and G G Illei

Ann Rheum Dis 2006; 65: 1330-1335.
Published Online First: 10 April 2006. doi:10.1136/ard.2006.051623

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Bosentan treatment for pulmonary arterial hypertension related to connective tissue disease: a subgroup analysis of the pivotal clinical trials and their open-label extensions

C P Denton, M Humbert, L Rubin, and C M Black

Ann Rheum Dis 2006; 65: 1336-1340.
Published Online First: 22 June 2006. doi:10.1136/ard.2005.048967

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Cutaneous abnormalities in rheumatoid arthritis compared with non-inflammatory rheumatic conditions

K M J Douglas, E Ladoyanni, G J Treharne, E D Hale, N Erb, and G D Kitas

Ann Rheum Dis 2006; 65: 1341-1345.
Published Online First: 13 February 2006. doi:10.1136/ard.2005.048934

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Indications for total hip replacement: comparison of assessments of orthopaedic surgeons and referring physicians

K E Dreinhöfer, P Dieppe, T Stürmer, D Gröber-Grätz, M Flören, K-P Günther, W Puhl, and H Brenner

Ann Rheum Dis 2006; 65: 1346-1350.
Published Online First: 26 January 2006. doi:10.1136/ard.2005.047811

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Differential expression patterns of recombination-activating genes in individual mature B cells in juvenile idiopathic arthritis

C Faber, H Morbach, S K Singh, and H J Girschick

Ann Rheum Dis 2006; 65: 1351-1356.
Published Online First: 27 February 2006. doi:10.1136/ard.2005.047878

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Etanercept and sulfasalazine, alone and combined, in patients with active rheumatoid arthritis despite receiving sulfasalazine: a double-blind comparison

B Combe, C Codreanu, U Fiocco, M Gaubitz, P P Geusens, T K Kvien, K Pavelka, P N Sambrook, J S Smolen, J Wajdula, S Fatenejad for the Etanercept European Investigators Network (The Etanercept Study 309 Investigators)

Ann Rheum Dis 2006; 65: 1357-1362.
Published Online First: 10 April 2006. doi:10.1136/ard.2005.049650

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Clinical classification criteria for knee osteoarthritis: performance in the general population and primary care

G Peat, E Thomas, R Duncan, L Wood, E Hay, and P Croft

Ann Rheum Dis 2006; 65: 1363-1367.
Published Online First: 20 April 2006. doi:10.1136/ard.2006.051482

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Sex differences in gout epidemiology: evaluation and treatment

L R Harrold, R A Yood, T R Mikuls, S E Andrade, J Davis, J Fuller, K A Chan, D Roblin, M A Raebel, A Von Worley, R Platt, and K G Saag

Ann Rheum Dis 2006; 65: 1368-1372.
Published Online First: 27 April 2006. doi:10.1136/ard.2006.051649

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Performance of response criteria for assessing peripheral arthritis in patients with psoriatic arthritis: analysis of data from randomised controlled trials of two tumour necrosis factor inhibitors

J Fransen, C Antoni, P J Mease, W Uter, A Kavanaugh, J R Kalden, and P L C M Van Riel

Ann Rheum Dis 2006; 65: 1373-1378.
Published Online First: 27 April 2006. doi:10.1136/ard.2006.051706

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Adalimumab and methotrexate is more effective than adalimumab alone in patients with established rheumatoid arthritis: results from a 6-month longitudinal, observational, multicentre study

M S Heiberg, E Rødevand, K Mikkelsen, C Kaufmann, A Didriksen, P Mowinckel, and T K Kvien

Ann Rheum Dis 2006; 65: 1379-1383.
Published Online First: 5 May 2006. doi:10.1136/ard.2006.051540

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Radiation synovectomy with yttrium-90 for persisting arthritis has direct harmful effects on human cartilage that cannot be prevented by co-administration of glucocorticoids: an in vitro study

Z N Jahangier, K M G Jacobs, J W J Bijlsma, and F P J G Lafeber

Ann Rheum Dis 2006; 65: 1384-1389.
Published Online First: 27 April 2006. doi:10.1136/ard.2005.045989

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Concise reports:

Down regulation of multidrug resistance protein-1 expression in patients with early rheumatoid arthritis exposed to methotrexate as a first disease-modifying antirheumatic drug

S L Hider, A Owen, R Hartkoorn, S Khoo, D Back, A J Silman, and I N Bruce

Ann Rheum Dis 2006; 65: 1390-1393.
Published Online First: 27 February 2006. doi:10.1136/ard.2005.049189

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Association of polymorphisms in the peroxisome proliferator-activated receptor gene and osteoarthritis of the knee

S Cheng, H Afif, J Martel-Pelletier, M Benderdour, J-P Pelletier, G Hilal, P Haraoui, J-P Raynauld, D Choquette, and H Fahmi

Ann Rheum Dis 2006; 65: 1394-1397. doi:10.1136/ard.2006.051904

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Letters:

Treatment of mesenteric angina with prolonged anticoagulation in a patient with antiphospholipid (Hughes) syndrome and coeliac artery stenosis

E Rosenthal, S R Sangle, P Taylor, M A Khamashta, G R V Hughes, and D P D’Cruz

Ann Rheum Dis 2006; 65: 1398-1399. doi:10.1136/ard.2005.050344

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Evaluation of allele frequencies in the PADI4 gene and anti-cyclic citrullinated peptide antibodies of patients with rheumatoid arthritis in a Japanese population

M Suzuki, J Miyagi, M Kuribayashi, E Negishi, K Ueno, and H Moriya

Ann Rheum Dis 2006; 65: 1399-1400. doi:10.1136/ard.2006.052431

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