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We read with interest the article by Moreno-Moral et al1 exploring the contribution of monocyte-derived macrophages (MDMs) in mediating genetic susceptibility to systemic sclerosis (SSc). By conducting RNA sequencing and genome-wide genotyping in a model of MDMs differentiated by macrophage colony-stimulating factor (M-CSF), this article provides new insights in the activation/polarisation states of blood MDMs in SSc.
In this work, the blood MDMs from 57 patients with SSc present a mixed activation signature state (figure 1 in ref.1): on the one hand, the down-regulation of interferon gamma response is in favour …
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