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Response to: ‘Calprotectin is not independent from baseline erosion in predicting radiological progression in early rheumatoid arthritis’ by Chevreau et al
  1. Maria Karolina Jonsson1,2,
  2. Nina Paulshus Sundlisæter2,
  3. Hilde Haugedal Nordal1,3,
  4. Hilde Berner Hammer2,
  5. Anna-Birgitte Aga2,
  6. Désirée van der Heijde2,4,
  7. Tore Kristian Kvien2,
  8. Bjørg-Tilde Svanes Fevang1,3,
  9. Siri Lillegraven2,
  10. Espen Andre Haavardsholm2,5
  1. 1Bergen Group of Epidemiology and Biomarkers in Rheumatic Disease, Department of Rheumatology, Haukeland University Hospital, Bergen, Norway
  2. 2Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
  3. 3Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway
  4. 4Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
  5. 5Institute of Health and Society, University of Oslo, Oslo, Norway
  1. Correspondence to Dr Maria Karolina Jonsson, Bergen Group of Epidemiology and Biomarkers in Rheumatic Disease, Department of Rheumatology, Haukeland University Hospital, Bergen 5021, Norway; jonssonmk{at}gmail.com

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We appreciate the additional data regarding calprotectin and radiographic progression provided by Chevreau et al1 as an eLetter addressing our published research paper.2 It is important to explore new biomarkers in different cohorts of patients with early and established rheumatoid arthritis (RA). Calprotectin levels have previously been shown to be associated with joint damage in established RA.3 4 Hammer et al5 have shown that calprotectin was an independent predictor of radiographic joint damage after 10 years of follow-up. Chevreau et al present data on baseline calprotectin as a predictor of rapid radiographic progression (defined as an increase of ≥5 van der Heijde Sharp score units/year) in a large cohort of patients with early RA, and did not find calprotectin to be associated with structural damage when baseline erosions were …

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