Article Text

PDF
Response to: ‘Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases’ by Visser et al
  1. Rochelle D Vergroesen1,
  2. Linda M Slot1,
  3. Lise Hafkenscheid1,
  4. Marvyn T Koning2,
  5. Hans U Scherer1,
  6. René E M Toes1
  1. 1Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
  2. 2Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands
  1. Correspondence to Dr Hans U Scherer, Department of Rheumatology, Leiden University Medical Center, 2300RC Leiden, The Netherlands; H.U.Scherer{at}lumc.nl

Statistics from Altmetric.com

We thank Visser et al1 for their interesting correspondence to our recently published letter entitled ‘B-cell receptor sequencing of anticitrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutation’.2 Visser et al performed a meta-analysis on publicly available datasets to analyse acquired N-glycosylation sites in the variable region of B cell receptors (BCRs) derived from patients with different autoimmune diseases. BCR sequences of antigen-specific B cells isolated after vaccination or infection and BCR sequences of healthy donors (HD) served as comparison. The meta-analysis showed acquired N-glycosylation sites in 9% of BCR sequences derived from patients with autoimmune diseases and in 2.3% and 2.7% of sequences derived from HD and vaccine/infection-induced B cells, respectively. This enhanced frequency of acquired N-glycosylation sites (compared with controls) was observed for all autoimmune diseases, with the exception of ankylosing spondylitis (AS, 3%) …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles