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  • Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density

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Clinical and epidemiological research
Extended report
Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density

Authors

  • Nerea Alonso Rheumatology and Bone Disease Unit, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Karol Estrada Departments of Internal Medicine and Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Omar M E Albagha Rheumatology and Bone Disease Unit, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar PubMed articlesGoogle scholar articles
  • Lizbeth Herrera Departments of Internal Medicine and Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Sjur Reppe Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway Department of Clinical Biochemistry, Lovisenberg Diakonale Hospital, Oslo, Norway Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway PubMed articlesGoogle scholar articles
  • Ole K Olstad Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway PubMed articlesGoogle scholar articles
  • Kaare M Gautvik Department of Clinical Biochemistry, Lovisenberg Diakonale Hospital, Oslo, Norway Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway PubMed articlesGoogle scholar articles
  • Niamh M Ryan Centre for Genomic and Experimental Medicine, IGMM, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Kathryn L Evans Centre for Genomic and Experimental Medicine, IGMM, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Carrie M Nielson Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, Oregon, USA PubMed articlesGoogle scholar articles
  • Yi-Hsiang Hsu Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA BROAD Institute of MIT and Harvard, Cambridge, Massachusetts, USA Musculoskeletal Research Center, Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Douglas P Kiel BROAD Institute of MIT and Harvard, Cambridge, Massachusetts, USA Musculoskeletal Research Center, Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • George Markozannes Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece PubMed articlesGoogle scholar articles
  • Evangelia E Ntzani Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece Centre for Evidence Synthesis in Health, Department of Health Services, Policy and Practice, School of Public Health, Brown University, Rhode Island, USA PubMed articlesGoogle scholar articles
  • Evangelos Evangelou Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece Department of Epidemiology and Biostatistics, Imperial College London, London, UK PubMed articlesGoogle scholar articles
  • Bjarke Feenstra Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark PubMed articlesGoogle scholar articles
  • Xueping Liu Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark PubMed articlesGoogle scholar articles
  • Mads Melbye Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Department of Medicine, Stanford School of Medicine, Stanford, California, USA PubMed articlesGoogle scholar articles
  • Laura Masi Department of Surgery and Translational Medicine, University of Florence, Florence, Italy PubMed articlesGoogle scholar articles
  • Maria Luisa Brandi Department of Surgery and Translational Medicine, University of Florence, Florence, Italy PubMed articlesGoogle scholar articles
  • Philip Riches Rheumatology and Bone Disease Unit, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Anna Daroszewska Rheumatology and Bone Disease Unit, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK Institute of Ageing and Chronic Disease, The MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
  • José Manuel Olmos Department of Internal Medicine, Hospital UM Valdecilla, University of Cantabria, IDIVAL, RETICEF, Santander, Spain PubMed articlesGoogle scholar articles
  • Carmen Valero Department of Internal Medicine, Hospital UM Valdecilla, University of Cantabria, IDIVAL, RETICEF, Santander, Spain PubMed articlesGoogle scholar articles
  • Jesús Castillo Department of Internal Medicine, Hospital UM Valdecilla, University of Cantabria, IDIVAL, RETICEF, Santander, Spain PubMed articlesGoogle scholar articles
  • José A Riancho Department of Internal Medicine, Hospital UM Valdecilla, University of Cantabria, IDIVAL, RETICEF, Santander, Spain PubMed articlesGoogle scholar articles
  • Lise B Husted Department of Endocrinology and Internal Medicine THG, Aarhus University Hospital, Aarhus, Denmark PubMed articlesGoogle scholar articles
  • Bente L Langdahl Department of Endocrinology and Internal Medicine THG, Aarhus University Hospital, Aarhus, Denmark PubMed articlesGoogle scholar articles
  • Matthew A Brown Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia PubMed articlesGoogle scholar articles
  • Emma L Duncan Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia Department of Endocrinology, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia PubMed articlesGoogle scholar articles
  • Stephen Kaptoge Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Kay-Tee Khaw Department of Public Health and Primary Care, School of Medicine, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Ricardo Usategui-Martín Molecular Medicine Unit, Department of Medicine and Biomedical Research Institute of Salamanca (IBSAL), University Hospital of Salamanca, University of Salamanca – CSIC, Salamanca, Spain PubMed articlesGoogle scholar articles
  • Javier Del Pino-Montes Molecular Medicine Unit, Department of Medicine and Biomedical Research Institute of Salamanca (IBSAL), University Hospital of Salamanca, University of Salamanca – CSIC, Salamanca, Spain PubMed articlesGoogle scholar articles
  • Rogelio González-Sarmiento Molecular Medicine Unit, Department of Medicine and Biomedical Research Institute of Salamanca (IBSAL), University Hospital of Salamanca, University of Salamanca – CSIC, Salamanca, Spain PubMed articlesGoogle scholar articles
  • Joshua R Lewis School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia Centre for Kidney Research, School of Public Health, University of Sydney, Sydney, New South Wales, Australia School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia PubMed articlesGoogle scholar articles
  • Richard L Prince School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia PubMed articlesGoogle scholar articles
  • Patrizia D’Amelio Gerontology and Bone Metabolic Diseases Unit, Department of Medical Science, University of Torino, Torino, Italy PubMed articlesGoogle scholar articles
  • Natalia García-Giralt Department of Internal Medicine, Hospital del Mar-IMIM, RETICEF, Universitat Autonoma de Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Xavier Nogués Department of Internal Medicine, Hospital del Mar-IMIM, RETICEF, Universitat Autonoma de Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Simona Mencej-Bedrac Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia PubMed articlesGoogle scholar articles
  • Janja Marc Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia PubMed articlesGoogle scholar articles
  • Orit Wolstein Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • John A Eisman Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia PubMed articlesGoogle scholar articles
  • Ling Oei Departments of Internal Medicine and Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Carolina Medina-Gómez Departments of Internal Medicine and Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Katharina E Schraut Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK Edinburgh/British Heart Foundation Centre for Cardiovascular Science, QMRI, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Pau Navarro MRC Human Genetics Unit, MRC, IGMM, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • James F Wilson Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK MRC Human Genetics Unit, MRC, IGMM, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Gail Davies Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • John Starr Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Ian Deary Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Toshiko Tanaka Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA PubMed articlesGoogle scholar articles
  • Luigi Ferrucci Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA PubMed articlesGoogle scholar articles
  • Fernando Gianfrancesco Institute of Genetics and Biophysics "Adriano Buzzati-Traverso", National Research Council of Italy, Naples, Italy PubMed articlesGoogle scholar articles
  • Luigi Gennari Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy PubMed articlesGoogle scholar articles
  • Gavin Lucas Grup de Recerca en Genètica i Epidemiologia Cardiovascular, IMIM, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Roberto Elosua Grup de Recerca en Genètica i Epidemiologia Cardiovascular, IMIM, Barcelona, Spain PubMed articlesGoogle scholar articles
  • André G Uitterlinden Departments of Internal Medicine and Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Fernando Rivadeneira Departments of Internal Medicine and Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Stuart H Ralston Rheumatology and Bone Disease Unit, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Stuart H Ralston, Rheumatology and Bone Disease Unit, Centre for Genomic and Experimental Medicine, IGMM University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK; stuart.ralston{at}ed.ac.uk
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Citation

Alonso N, Estrada K, Albagha OME, et al
Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density
Annals of the Rheumatic Diseases 2018;77:378-385.

Publication history

  • Received September 29, 2017
  • Accepted November 1, 2017
  • First published November 23, 2017.
Online issue publication 
April 19, 2018

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