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Correspondence response
Amino-bisphosphonates, γδT cells, and their roles in Rheumatoid Arthritis
  1. Wen-Xiu Mo,
  2. Shan-Shan Yin,
  3. Hua Chen,
  4. Xuan Zhang
  1. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Ministry of Education Key Laboratory, Beijing, China
  1. Correspondence to Professor Xuan Zhang, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, The Ministry of Education Key Laboratory, Beijing 100730, China; zxpumch2003{at}sina.com

https://doi.org/10.1136/annrheumdis-2017-212569

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    We thank Dr Rossini and colleagues1 for their interesting comments on our manuscript.2

    Aminobisphosphonates (N-BPs), the analogue of isopentenyl pyrophosphate, promote the activation and proliferation of peripheral γδ T cells, specifically Vγ9/Vδ2 T cells,3 which are the cells we showed that play an important role in the pathogenesis of rheumatoid arthritis (RA).2 We fully agree that γδ T cells are one of the major factors that may contribute to N-BPs-related acute phase response …

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    Footnotes

    • Contributors All authors equally contributed to the writing of the manuscript. HC and XZ are the corresponding authors.

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.

    Linked Articles

    • Correspondence
      Rheumatoid arthritis, γδ T cells and bisphosphonates
      Maurizio Rossini Giovanni Adami Ombretta Viapiana Luca Idolazzi Angelo Fassio Alessandro Giollo Cristian Caimmi Giovanni Orsolini Davide Gatti
      Annals of the Rheumatic Diseases 2017; 77 e57-e57 Published Online First: 26 Oct 2017. doi: 10.1136/annrheumdis-2017-212510