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Amino-bisphosphonates, γδT cells, and their roles in Rheumatoid Arthritis
  1. Wen-Xiu Mo,
  2. Shan-Shan Yin,
  3. Hua Chen,
  4. Xuan Zhang
  1. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Ministry of Education Key Laboratory, Beijing, China
  1. Correspondence to Professor Xuan Zhang, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, The Ministry of Education Key Laboratory, Beijing 100730, China; zxpumch2003{at}sina.com

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We thank Dr Rossini and colleagues1 for their interesting comments on our manuscript.2

Aminobisphosphonates (N-BPs), the analogue of isopentenyl pyrophosphate, promote the activation and proliferation of peripheral γδ T cells, specifically Vγ9/Vδ2 T cells,3 which are the cells we showed that play an important role in the pathogenesis of rheumatoid arthritis (RA).2 We fully agree that γδ T cells are one of the major factors that may contribute to N-BPs-related acute phase response …

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