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Response to: ’Uric acid and incident dementia: a population-based cohort study' by Lee and Song
  1. Augustin Latourte1,2,
  2. Aicha Soumaré3,
  3. Thomas Bardin1,2,
  4. Stéphanie Debette3,4,5,6,
  5. Pascal Richette1,2
  1. 1Rheumatology Department, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France
  2. 2Inserm U1219, UFRde Médecine, Université Paris Diderot, Paris, France
  3. 3Inserm Centre Bordeaux Population Health (U1219), Bordeaux, France
  4. 4University of Bordeaux, Bordeaux, France
  5. 5Department of Neurology, Memory Clinic, Bordeaux, France
  6. 6Department of Neurology, Framingham Heart Study, Boston University School of Medicine, Boston, USA
  1. Correspondence to Professor Pascal Richette, Rheumatology Department, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Inserm U1132, UFR de Médecine, Université Paris Diderot, Paris 75013, France; pascal.richette{at}aphp.fr

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We thank Drs Lee and Song for their interest and comments concerning our recent population-based cohort study investigating the relationship between serum uric acid (SUA) levels and dementia in elderly patients.1 2 They shared their concerns about the association that we found between higher SUA levels at baseline and an increased risk of incident vascular or mixed dementia. As discussed in our paper, these findings contradict a previous prospective study conducted in the Rotterdam cohort, which suggested that higher SUA levels were associated with a decreased risk of dementia and better cognitive function later in life.3

Drs Lee and Song highlighted that the association between higher SUA levels …

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