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Response to: ‘Spontaneous hypertensive rat exhibits bone and meniscus phenotypes of osteoarthritis: is it an appropriate control for MetS-associated OA?’ by Chan and Wen
  1. Chaohua Deng1,2,
  2. Arnaud Bianchi1,2,
  3. Nathalie Presle1,2,
  4. David Moulin1,2,3,
  5. Meriem Koufany1,2,
  6. Cécile Guillaume1,2,
  7. Hervé Kempf1,2,*,
  8. Anne Pizard2,3,4,5
  1. 1UMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire, Vandoeuvre-lès-Nancy, Lorraine, France
  2. 2Fédération de Recherche 3209, Université de Lorraine, Vandoeuvre-lès-Nancy, Lorraine, France
  3. 3CHRU, Nancy, Vandoeuvre-lès-Nancy, Lorraine, France
  4. 4UMRS U1116 Inserm, Université de Lorraine, DCAC, Vandoeuvre-lès-Nancy, Lorraine, France
  5. 5CIC-P 1433 Inserm, CHU Nancy, Vandoeuvre-lès-Nancy, Lorraine, France
  1. Correspondence to Hervé Kempf, UMR 7365 CNRS-UL, IMoPA, 9 avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy 54500 France; herve.kempf{at}inserm.fr and Dr Anne Pizard, Inserm U1116, CHRU Nancy, 4 rue du Morvan, Vandoeuvre-lès-Nancy 54500, France; anne.pizard{at}inserm.fr

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We thank Dr Chan and Dr Wen for their interest in our report1 and their resulting eLetter.2 We fully agree that, among the different components of metabolic syndrome (MetS), hypertension has very recently been brought out as a critical feature in the development of osteoarthritis (OA) in humans.3 4 In these reports using either data from the Framingham OA study3 or the Osteoarthritis Initiative study,4 it has been emphasised that high blood pressure (diastolic or systolic, respectively) was associated with increased incidence of radiographic knee OA.

In order to further experimentally investigate the actual role of hypertension in OA onset and development, Chan and colleagues describe in a yet unpublished study the development of OA features in the spontaneous hypertensive rat (SHR) model, a widely characterised model of systemic hypertension.2 5 Although the spontaneous hypertensive heart failure (SHHF) rat strain we employed is deriving from the SHR strain6 and suffers high …

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