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I thank Valiyil and Schechter for their letter1 to the editorial related to clinical studies of lesinurad.2 The letter correctly states that the 200 mg lesinurad dose is the only (initial and maximum) dose that should be prescribed to patients, always in combination with a xanthine oxidase inhibitor. The letter provides an important clarification regarding the dose of lesinurad that was approved by the regulatory agencies. Based on higher toxicity, the sponsor did not pursue regulatory approval (Food and Drug Administration (FDA) and European Medicines Agency (EMEA)) for …
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