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Lesinurad combination therapy with allopurinol in gout: do CLEAR studies make the treatment of gout clearer?
  1. Ritu Valiyil,
  2. Bruce Schechter
  1. Ironwood Pharmaceuticals, Cambridge, Massachusetts, USA
  1. Correspondence to Dr Ritu Valiyil, Ironwood Pharmaceuticals Inc, Cambridge, MA 02142, USA; rvaliyil{at}ironwoodpharma.com

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In his recent editorial commenting on the Combining Lesinurad with Allopurinol in Inadequate Responders studies,1 Dr Singh provides a thorough overview of the phase 3 trials demonstrating the efficacy and safety of lesinurad given in combination with allopurinol for the treatment of gout in patients who do not reach serum uric acid goal on …

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